Meta-analysis Report
Basic Info
| Reference |
Zou, Y. F.,2011 PMID: 21314245
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| Citation |
Zou, Y. F., F. Wang, et al. (2011). "Meta-analysis of ACE gene I/D polymorphism and bipolar disorder susceptibility." Nord J Psychiatry 65(4): 276-282.
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| Disease Type |
Bipolar Disorder |
| Study Type |
Candidate-gene association study |
Detail Info
| Samples |
Seven studies that included data from 605 cases and 1541 controls |
| Statistic Method |
The odds ratio (OR) and its 95% confidence interval (95% CI) were estimated for each study. Statistical heterogeneity among studies was tested with the Q statistic.In addition, publication bias was investigated with the funnel plot. Funnel plot asymmetry was further assessed by the method of Egger's linear regression test. Analyses were performed using the software Review Manager 4.2 (Cochrane Collaboration, http://www.cc-ims. net/RevMan/relnotes.htm/) and Stata version 10 (StataCorp LP, College Station, TX, USA). |
| Basic Result |
Seven studies that included data from 605 cases and 1541 controls were identified. When all groups were pooled, we did not detect the association of ACE gene I/D polymorphism with BPD (P > 0.05). In the subgroup analysis, we did not detect the association of ACE gene I/D polymorphism with BPD in Caucasians (P > 0.05). An association of ACE gene I/D polymorphism with BPD was found in Asians for the contrast of DD vs. ID + II (OR = 2.01, 95% CI 1.08-3.74, P = 0.03), but not for other contrasts (P > 0.05). CONCLUSIONS: This meta-analysis suggests that there may be an association of ACE gene I/D polymorphism with BPD in Asians. Further studies are still needed in Asians. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| ACE insertion/deletion |
ACE |
insertion/deletion |
insertion/deletion |
|
When all groups were pooled, the association of ACE gene I/D polymorphism with BPD :P > 0.05. In the subgroup analysis, the association of ACE gene I/D polymorphism with BPD in Caucasians:P > 0.05. Association of ACE gene I/D polymorphism with BPD in Asians for the contrast of DD vs. ID + II (OR = 2.01, 95% CI 1.08-3.74, P-value = 0.03), for other contrasts (P > 0.05).
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An association of ACE gene I/D polymorphism with BPD was fou......
An association of ACE gene I/D polymorphism with BPD was found in Asians.
More...
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Positive
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Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| ACE |
This meta-analysis suggests that there may be an association of ACE gene I/D polymorphism with BPD i......
This meta-analysis suggests that there may be an association of ACE gene I/D polymorphism with BPD in Asians.
More...
|
Positive
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