Study Report

Reference	Georgieva, L.,2002 PMID: 11942948
Citation	Georgieva, L., A. Dimitrova, et al. (2002). "Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population." Acta Psychiatr Scand 105(5): 396-399.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	SZ (178 trios), BPI (77 trios) and SA (29 trios)
SNP/Region/Marker Size	1 variant
Predominant Ethnicity	Caucasian
Population	Bulgarian
Gender	Male/female:88/90 for SZ probands,35/42 for BPD probands and 13/16 for SA probands
Age Group	Adults : Mean age(SD)(year):32.9(8.2) for SZ probands,31.2(9.4) for BP probands and 33.5(8.3) for SA probands

Sample Diagnosis	DSM
Sample Status	The total sample presented here consisits of 284 families from Bulgarian origin. The probands were either in-patients from two different universitu psychiatric hospitals or outpatients from two of the largest psychiatric dispensaries in Bulgaria.
Technique	PCR
Statistical Method	the extended TDT (ETDT)
Result Summary	No preferential transmission of alleles was observed for any diagnostic group. The presence of allele DAT*10 was associated with the severity and frequency of auditory hallucinations, however, this result is not significant if corrected for multiple testing.CONCLUSION: Our results are in agreement with previous reports of a lack of association between this polymorphism and major psychiatric disorders.