SNP Report

Basic Info

Name	rs1386491 dbSNP Ensembl
Location	chr12:71968598 - 71968598(1)
Variant Alleles	G/C
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.188498
Functional Annotation	downstream_gene_variant; intron_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000546576); intron_variant(ENST00000333850)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Roche, S.,2009		G	TDT: X²=1.175, P-value = 0.2784 TDT: X²=1.175, P-value = 0.2784	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TPH2	tryptophan hydroxylase 2	12q15	13(10/3/0)

SNPs in LD with rs1386491 (count: 13) View in gBrowse (chr12:71948504..72014217 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs17110627	intron_variant	0.94[CEU]
rs1023990	intron_variant	0.945[CEU]
rs10506646	intron_variant	0.94[CEU]
rs11179002	intron_variant; non_coding_transcript_variant	0.942[CEU]
rs17110532	intron_variant	0.932[CEU]
rs17110690	intron_variant	0.94[CEU]
rs11179023	intron_variant	0.94[CEU]
rs1487278	intron_variant	0.888[CEU]
rs17110489	intron_variant; non_coding_transcript_variant	0.94[CEU]
rs17110540	intron_variant	0.94[CEU]
rs17110536	intron_variant	0.94[CEU]
rs11179033	intron_variant	0.829[CEU]
rs12319219	intron_variant	0.805[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)