Gene Report

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Basic Info

Approved Symbol	KPNA5
Symbol Alias	SRP6, IPOA6
Approved Name	karyopherin alpha 5 (importin alpha 6)
Location	6q22.2
Position	chr6:116681187-116741866, 1
External Links	HGNC: 6398 Entrez Gene: 3841 Ensembl: ENSG00000196911 UCSC: uc003pxh.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010		For gene-based test, P-value = 0.33 in STEP1; P-value = 0.02 in NIMH; P-value = 0.048 in STEP1 and NIMH. nominally significant in NIMH sample and pooled sample, but not survive Bonferroni correction test.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006607	NLS-bearing protein import into nucleus	biological process	TAS[9395085]	1
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	23
GO:0005515	protein binding	molecular function	IPI[15057270]	563
GO:0005829	cytosol	cellular component	TAS	223
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0008565	protein transporter activity	molecular function	IEA	4
GO:0005654	nucleoplasm	cellular component	TAS	163

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
KPNA5	ANP32A	NO	yeast 2-hybrid	16713569
KPNA5	BRMS1	NO	yeast 2-hybrid	16919237
KPNA5	CDKN1B	NO	in vitro	15057270

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q22.1-6q22.33	chr6:114200000-130000000	1 (0/1/0)
6q21-22	chr6:105000000-130000000	1 (0/0/1)
6q22	chr6:114200000-130000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:116681187..116741866 View in gBrowse