Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	GCLC
Previous Symbol	GLCLC, GLCL
Symbol Alias	GCS
Approved Name	glutamate-cysteine ligase, catalytic subunit
Location	6p12
Position	chr6:53497341-53616970, -1
External Links	HGNC: 4311 Entrez Gene: 2729 Ensembl: ENSG00000001084 UCSC: uc003pbw.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fullerton, J. M.,2010	Other variant: GCLC_5'UTR_repeat	No association was detected with the gene encoding GCLC.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 33)

GO terms by PBA (count: 0)

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0009408	response to heat	biological process	IDA[8104187]	12
GO:0017109	glutamate-cysteine ligase complex	cellular component	IBA	2
GO:0006750	glutathione biosynthetic process	biological process	IDA[10395918]; IEA; IMP[12663448]; TAS	3
GO:0019852	L-ascorbic acid metabolic process	biological process	IEA	1
GO:0006536	glutamate metabolic process	biological process	IDA[12663448]	2
GO:0050662	coenzyme binding	molecular function	IPI[9675072]	3
GO:0031397	negative regulation of protein ubiquitination	biological process	IEA	6
GO:0043066	negative regulation of apoptotic process	biological process	IDA[10439045]	46
GO:0006979	response to oxidative stress	biological process	IDA[10395918]	11
GO:0016595	glutamate binding	molecular function	IDA[9841880]	6
GO:0043524	negative regulation of neuron apoptotic process	biological process	IEA	26
GO:0006534	cysteine metabolic process	biological process	IDA[2294991]	2
GO:0050880	regulation of blood vessel size	biological process	IMP[12598062]	5
GO:0051409	response to nitrosative stress	biological process	IEA	3
GO:0000287	magnesium ion binding	molecular function	IDA[24639]	11
GO:0051900	regulation of mitochondrial depolarization	biological process	IEA	2
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0009725	response to hormone	biological process	IDA[8104187]	4
GO:0043531	ADP binding	molecular function	IDA[24639]	4
GO:0046685	response to arsenic-containing substance	biological process	IEA	2
GO:1901687	glutathione derivative biosynthetic process	biological process	TAS	6
GO:0046982	protein heterodimerization activity	molecular function	IEA	42
GO:0005829	cytosol	cellular component	TAS	223
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological process	IEA	7
GO:0045454	cell redox homeostasis	biological process	IDA[10439045]	4
GO:0000096	sulfur amino acid metabolic process	biological process	TAS	3
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	20
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[10439045]	43
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	biological process	IEA	6
GO:0004357	glutamate-cysteine ligase activity	molecular function	IDA[11972604]; IMP[16183645]	2
GO:0008637	apoptotic mitochondrial changes	biological process	IEA	4
GO:0005524	ATP binding	molecular function	IEA	118
GO:0006805	xenobiotic metabolic process	biological process	TAS	19

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00251	Glutamate metabolism	5
hsa00480	Glutathione metabolism	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
GCLC_5'UTR_repeat	microsatellite	5'UTR	1 (0/1/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6p12-q13	chr6:46200000-75200000	1 (0/1/0)
Chr 6	chr6:0-170805979	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:53497341..53616970 View in gBrowse