Gene Report

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Basic Info

Approved Symbol	DNAH3
Symbol Alias	Dnahc3b, DLP3, Hsadhc3, DKFZp434N074
Approved Name	dynein, axonemal, heavy chain 3
Previous Name	dynein, axonemal, heavy polypeptide 3
Location	16p12.2
Position	chr16:20933111-21159441, -1
External Links	HGNC: 2949 Entrez Gene: 55567 Ensembl: ENSG00000158486 UCSC: uc010vbe.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs330150	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001539	cilium or flagellum-dependent cell motility	biological process	NAS[9256245]	1
GO:0007018	microtubule-based movement	biological process	IEA	7
GO:0005874	microtubule	cellular component	IEA	24
GO:0005524	ATP binding	molecular function	IEA	118
GO:0008152	metabolic process	biological process	IEA; NAS[9256245]	50
GO:0003777	microtubule motor activity	molecular function	NAS[9256245]	8
GO:0005858	axonemal dynein complex	cellular component	NAS[9256245]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs330150	chr16:21039887 - 21039887(1)	missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs2545886	chr16:21017875 - 21017875(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs2172436	chr16:21012711 - 21012711(1)	intron_variant; non_coding_transcript_variant
rs330138	chr16:21050387 - 21050387(1)	intron_variant; non_coding_transcript_variant
rs330149	chr16:21040679 - 21040679(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs330136	chr16:21053063 - 21053063(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)
16p12	chr16:16700000-28500000	2 (1/1/0)
16p12.3-p13.1	chr16:10400000-21200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr16:20933111..21159441 View in gBrowse