Gene Report

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Basic Info

Approved Symbol	CEP72
Symbol Alias	KIAA1519, FLJ10565
Approved Name	centrosomal protein 72kDa
Location	5p15.33
Position	chr5:612272-667168, 1
External Links	HGNC: 25547 Entrez Gene: 55722 Ensembl: ENSG00000112877 UCSC: uc003jbf.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042802	identical protein binding	molecular function	IEA	44
GO:0006996	organelle organization	biological process	TAS	23
GO:0005829	cytosol	cellular component	TAS	223
GO:0005515	protein binding	molecular function	IPI[19536135]	563
GO:0005813	centrosome	cellular component	IDA[19536135]	34
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS	15
GO:0007051	spindle organization	biological process	IMP[19536135]	2
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0033566	gamma-tubulin complex localization	biological process	IMP[19536135]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CEP72	KIAA0408	NO	yeast 2-hybrid	16189514
CEP72	ZBTB16	NO	yeast 2-hybrid	16189514
CEP72	PCM1	NO	yeast 2-hybrid	16189514
CEP72	MCM10	NO	yeast 2-hybrid	16189514
CEP72	LNX1	YES	yeast 2-hybrid	16189514
CEP72	IGHM	NO	yeast 2-hybrid	16189514
CEP72	SPATA2	NO	yeast 2-hybrid	16189514
CEP72	ZNF417	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_7	chr5:409381-706343 (NCBI Build 36/hg18)	297000	5p15.33	duplication

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5p15.33	chr5:0-4400000	1 (0/0/1)
5pter-p15.1	chr5:0-18400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:612272..667168 View in gBrowse