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Detail of comment on gene
By Lei Gao on 2013-03-21 15:31:40.0 | ||
Gene | CACNA1C | View all comments on gene Comment on gene |
Gene weighting | 3 - strong association | |
Comment | The A allele of the CACNA1C rs1006737 polymorphism is consistently associated with bipolar disorder (BD).It was reported that the presence of the A risk allele was associated with decreased outflow of information from medial frontal gyrus (MFG), which was significantly more marked in patients than in their unaffected relatives and healthy controls. | |
Reference | Radua, J., et al. (2012). "The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder." Mol Psychiatry. |
Replies for this comment
By Suhua Chang on 2013-03-21 15:55:42.0 | ||
Gene weighting | 3 - strong association | |
Comment | Reply for gene CACNA1C. This gene has been tested to be associated with BD in several GWAS. |
By Suhua Chang on 2013-03-26 11:46:17.0 | ||
Gene weighting | 2 - moderate association | |
Comment | Reply for gene CACNA1C: this gene is also involved in several pathways identified by PBA for GWAS. |
By Lei Gao on 2013-03-26 11:47:51.0 | ||
Comment | CACNA1C has been reported to be related gray matter volume. | |
Reference | Kempton MJ, Ruberto G, Vassos E, Tatarelli R, Girardi P, Collier D, et al. (2009): Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals. Am J Psychiatry. 166:1413-1414. |
By LCiJpzYc LCiJpzYc on 2024-07-20 06:28:32.0 | ||
Comment | 555 | |
Reference | 555 |