Detail of comment on gene

By Lei Gao on 2013-03-21 15:31:40.0
Gene	CACNA1C	View all comments on gene Comment on gene
Gene weighting	3 - strong association
Comment	The A allele of the CACNA1C rs1006737 polymorphism is consistently associated with bipolar disorder (BD).It was reported that the presence of the A risk allele was associated with decreased outflow of information from medial frontal gyrus (MFG), which was significantly more marked in patients than in their unaffected relatives and healthy controls.
Reference	Radua, J., et al. (2012). "The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder." Mol Psychiatry.

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By Suhua Chang on 2013-03-21 15:55:42.0
Gene weighting	3 - strong association
Comment	Reply for gene CACNA1C. This gene has been tested to be associated with BD in several GWAS.

By Suhua Chang on 2013-03-26 11:46:17.0
Gene weighting	2 - moderate association
Comment	Reply for gene CACNA1C: this gene is also involved in several pathways identified by PBA for GWAS.

By Lei Gao on 2013-03-26 11:47:51.0
Comment	CACNA1C has been reported to be related gray matter volume.
Reference	Kempton MJ, Ruberto G, Vassos E, Tatarelli R, Girardi P, Collier D, et al. (2009): Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals. Am J Psychiatry. 166:1413-1414.

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