BDgene

Detail of comment on gene

By Lei Gao on 2013-03-21 15:31:40.0
Gene CACNA1C
Gene weighting 3 - strong association
CommentThe A allele of the CACNA1C rs1006737 polymorphism is
consistently associated with bipolar disorder (BD).It was reported that the presence of the A risk allele was associated with decreased outflow of information from medial frontal gyrus (MFG), which was significantly more marked in patients than in their unaffected relatives and healthy controls.
ReferenceRadua, J., et al. (2012). "The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder." Mol Psychiatry.

Replies for this comment

By Suhua Chang on 2013-03-21 15:55:42.0
Gene weighting 3 - strong association
Comment Reply for gene CACNA1C. This gene has been tested to be associated with BD in several GWAS.

By Suhua Chang on 2013-03-26 11:46:17.0
Gene weighting 2 - moderate association
Comment Reply for gene CACNA1C: this gene is also involved in several pathways identified by PBA for GWAS.

By Lei Gao on 2013-03-26 11:47:51.0
Comment CACNA1C has been reported to be related gray matter volume.
ReferenceKempton MJ, Ruberto G, Vassos E, Tatarelli R, Girardi P, Collier D, et al. (2009): Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals. Am J Psychiatry. 166:1413-1414.

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