BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	NOS1 promoter VNTR
Type	VNTR
Location	promoter
Related Gene	NOS1
No. of Study	2 (Positive: 0; Negative 2; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Reif, A., 2006 (a)	L/S		P-value = 0.156, X²=3.71, df=2	neither VNTR1 nor SNP1 were significantly associated with BP..... More neither VNTR1 nor SNP1 were significantly associated with BPD Less	Negative
Silberberg, G.,2010	short/long		Association analysis:X²=2.9, genotypic P-value = 0.58	No significant association was observed in BD.	Negative

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Reif, A., 2006 (a)	P-value = 0.355, X²=2.07, df=2 in unsystematic SCZ, P-value = 0.429, X²=1.70, df=2 in systematic SCZ, P-value = 0.353, X²=2.08, df=2 in total sample with SCZ	schizophrenic patients did not differ significantly from controls in dichotomized VNTR1 genotype frequencies; there was no significant effect of VNTR1 with regard to the two SCZ subgroups.	Negative
Silberberg, G.,2010	Association analysis:X²=2.9, genotypic P-value = 0.58	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)