BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	NOS1 SNP1
Type	point mutation
Related Gene	NOS1
No. of Study	1 (Positive: 0; Negative 1; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Reif, A., 2006 (a)	A/G		P-value = 0.863, X²=0.03, df=1	neither VNTR1 nor SNP1 were significantly associated with BP..... More neither VNTR1 nor SNP1 were significantly associated with BPD Less	Negative

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Reif, A., 2006 (a)	P-value = 0.154, X²=2.03, df=2 in unsystematic SCZ, P-value = 0.004, X²=8.42, df=2 in systematic SCZ, P-value = 0.020, X²=5.42, df=2 in total sample with SCZ	SNP1 A/A and A/G genotypes were significantly more frequent among schizophrenic patients than among controls; there was no significant effect in the group A SCZ subgroup; the association between SNP1 and SCZ was mainly due to considerably higher frequencies of the A/A and A/ G genotypes in the group B SCZ subgroup	Positive

Overlap with MDD from cross-disorder studies (count: 0)