BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	GRIN2B T5988C
Type	point mutation
Related Gene	GRIN2B
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Martucci, L., 2006	T/C		FBAT P-value = 0.02, z=2.332, after correction for multiple testing P-value = 0.04 in BP triads, P-value = 0.051, z=1.945 for BP psychotic	In the bipolar sample, the 5988C allele was transmitted more..... More In the bipolar sample, the 5988C allele was transmitted more frequently in the complete bipolar sample. Less	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Martucci, L., 2006	P-value (corrected)=0.654, X²=0.849, df=2 of allele frequencies and association analysis in the schizophrenia case-control sample; FBAT P-value = 0.56, z=0.6 in SCZ triads	The T5988C polymorphism was not associated with schizophrenia in either sample.	Negative

Overlap with MDD from cross-disorder studies (count: 0)