BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Other Variant Report

Basic Info

Name	GABRA5 3'UTR 1-8 allele
Type	others
Related Gene	GABRA5
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Oruc, L., 1997 ( c)			Fisher exact test, P-value=0.168 of patients, P-value=0.591 of BP for allele 1, P-value=0.389 of patients, P-value=0.377 of BP for allele 2, P-value=0.138 of patients, P-value=0.155 of BP for allele 3, P-value=0.017 of patients, P-value=0.177 of BP for allele 4, P-value=0.521 of patients, P-value=1 of BP for allele 5, P-value=0.225 of patients, P-value=0.266 of BP for allele 5, P-value=0.657 of patients, P-value=0.162 of BP for allele 7, P-value=1 of patients, P-value=1 of BP for allele 8, P-value=0.075 of patients, P-value=0.680 of BP for total, Homozygotes P-value=0.855 of patients, P-value=0.493	ln this study an association was found with allele 4 (282 ba..... More ln this study an association was found with allele 4 (282 base pairs) of a dinucleotide repeat polymorphism localed in the 3'UTR of the GABRA5 gene in the overall patient sample. However, this p value did not remain significant after correcting for multiple testing. Less	Positive

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Oruc, L., 1997 ( c)	Fisher exact test, P-value=0.168 of patients, P-value=0.143 of UP for allele 1, P-value=0.389 of patients, P-value=0.597 of UP for allele 2, P-value=0.138 of patients, P-value=0.391 of UP for allele 3, P-value=0.017 of patients, P-value=0.0065 of UP for allele 4, P-value=0.521 of patients, P-value=0.259 of UP for allele 5, P-value=0.225 of patients, P-value=0.421 for allele 6, P-value=0.657 of patients for allele 7, P-value=1 of patients, P-value=1 of UP for allele 8, P-value=0.075 of patients, P-value=0.096 for total, Homozygotes P-value=0.855 of patients, P-value=0.803 of UP	A significant association was present in the UPR group. An increased frequency of allele 4 was also observed in subjects with BPI disorder, but the results did not reach statistical significance.	Positive