BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	5-HT2C Cys/Ser
Type	point mutation
Related Gene	HTR2C
No. of Study	1 (Positive: 0; Negative 1; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Mohammadi, S., 2015			genotypic P-value=0.98, X²=0.025, genotypic P-value=0.83, X²=0.36 in females; allelic P-value=0.95, X²=0.004, allelic P-value=0.78, X²=0.073 in females, allelic P-value=0.85, X²=0.05 in males	The frequency of 5-HT2C Ser allele in patients and controls ..... More The frequency of 5-HT2C Ser allele in patients and controls were 12.3 and 12.5%, respectively. Mutant allele of HT2C Ser had higher frequency in female (14.7%) than male (10.5%, p=0.27) patients. The frequency of HT2C Ser allele in patients with a family history of BID tended to be higher (15.7%) than those without a family history of the disease (11.8%). The frequency of HT2C Ser allele in suicide attempter women was higher (16.7%) than those without a suicide attempt (14.3%). Less	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)