BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Ozdemircan, A., 2015 PMID: 26609651
Citation	Ozdemircan, A., et al. (2015). "COX-2 gene variants in bipolar disorder-I." Psychiatr Danub 27(4): 385-389.
Disease Type	Bipolar disorder-I
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	180 subjects with bipolar I disorder-I and 170 non-bipolar subjects
Predominant Ethnicity
Population	from the psychiatric department of Istanbul Erenkoy Psychiatric and Neurological Disorders Hospital
Gender	63.3% male for patients, 72.4% male for controls
Age Group	adults : mean age (SD) = 38.75ï¼ˆ11.5ï¼‰ years for BD-I; mean age (SD) = 36.97ï¼ˆ10.5ï¼‰ years for healthy controls

Detail Info

Haplotypes reported by this study for BD (count: 4)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
	COX-2-765C: 1195G	COX-2	P-value=0.0371	COX-2-765G: 1195G and COX-2-765C: 1195G haplotype frequencie...... COX-2-765G: 1195G and COX-2-765C: 1195G haplotype frequencies were significantly higher in controls compared with those of patients. More...	Positive
	COX-2-765G: 1195A	COX-2	P-value=0.0099	Haplotype analysis confirmed the association of gene variant...... Haplotype analysis confirmed the association of gene variants with BD-I and revealed that the frequencies of COX-2-765G: 1195A haplotype frequencies were significantly higher in patients compared with those of controls. More...	Positive
	COX-2-765G: 1195G	COX-2	P-value=0.0018	COX-2-765G: 1195G and COX-2-765C: 1195G haplotype frequencie...... COX-2-765G: 1195G and COX-2-765C: 1195G haplotype frequencies were significantly higher in controls compared with those of patients. More...	Positive
	COX-2-765C: 1195A	COX-2	P-value=0.6456		Negative