Study Report

Basic Info
Reference |
Oruc, L., 1997 (b) PMID: 9342201
|
Citation |
Oruc, L., G. R. Verheyen, et al. (1997). "Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder." Am J Med Genet 74(5): 504-506.
|
Disease Type |
Bipolar I Disorder |
Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
42 patients with bipolar disorder type I (BPI) and 40 healthy controls |
SNP/Region/Marker Size |
2 polymorphisms |
Predominant Ethnicity |
|
Population |
Croatian |
Gender |
25 females and 17 males |
Age Group |
adults
:
31-70 years
|

Detail Info
Sample Diagnosis |
Research Diagnostic Criteria (RDC) |
Sample Status |
Forty-two unrelated patients with BP disorder type I (BPI) were recruited among in- and outpatients of the REBRO and Vrapce psychiatric hospitals in Zagreb, Croatia. Those who fulfilled Research Diagnostic Criteria (RDC) for BPI disorder were included. The mean age at onset was 31.7, SD=5.7 years. In our sample, 16 BPI patients had a positive family history as defined by at least one first-degree relative suffering from major affective disorders. |
Technique |
PCR amplification |
Statistical Method |
Hardy-Weinberg equilibrium within our populations was confirmed, using an exact test. The statistical significance of differences in specific allele and genotype frequencies, as well as homozygote/heterozygote frequencies between patient and control populations, was calculated using Fisher's exact test (two-sided). |
Result Summary |
No significant associations were found in the total patient sample. However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5-HTR2c and P = 0.049 for 5-HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women. |

Other variants reported by this study for BD (count: 2)
Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
5-HTR2C RFLP |
HTR2C |
SNP |
|
|
Fisher’s exact test, allelic P-value=0.071, genotypic P-value=0.051 for females, allelic P-value=0.092, genotypic P-value=0.092 for males; combined allelic P-value=0.426, genotypic P-value=0.407 of C,C or C, P-value=0.068 of C,S, P-value=0.112 of S,S or S
|
In this study we found no significant association of the RFL......
In this study we found no significant association of the RFLP polymorphism in the 5-HTR2c receptor gene with BPI disorder in the total patient sample.
More...
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Negative
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5-HTT PstI RFLP |
SLC6A4 |
SNP |
|
|
Fisher’s exact test, allelic P-value=0.049, genotypic P-value=0.081 for females, allelic P-value=0.413, genotypic P-value=0.384 for males; combined allelic P-value=0.303, genotypic P-value=0.407
|
We also did not find any significant association of the PstI......
We also did not find any significant association of the PstI RFLP polymorphism in the 5-HTT gene and BPI disorder.
More...
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Negative
|

Genes reported by this study for BD (count: 2)
Gene |
Statistical Values/Author Comments |
Result Category |
HTR2C |
These results suggest that variations in these genes may be responsible for a minor increase in susc......
These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women.
More...
|
Negative
|
SLC6A4 |
These results suggest that variations in these genes may be responsible for a minor increase in susc......
These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women.
More...
|
Negative
|