Study Report
Basic Info
| Reference |
Jun, T. Y., 2004 PMID: 14678452
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| Citation |
Jun, T. Y., K. U. Lee, et al. (2004). "No evidence for an association of the CTLA4 gene with bipolar I disorder." Psychiatry Clin Neurosci 58(1): 21-24.
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| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
90 bipolar disorder patients and 149 controls |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Mongloid |
| Population |
Korean |
| Gender |
patients with bipolar disorder (43 men and 47 women); healthy controls (68 men and 81 women) |
| Age Group |
adults
:
BD patients: mean age=34.9 (SD=11.0) years; healthy controls mean age=33.5 (SD=11.0) years
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Detail Info
| Sample Diagnosis |
DSM-IV |
| Technique |
PCR and genotyping |
| Statistical Method |
X2 test was used to analyze the difference in allele and genotype frequencies between the patients with bipolar disorder and the control group. P < 0.05 was considered statistically significant. |
| Result Summary |
There were no significant differences in genotype frequencies of CTLA4*G/G, CTLA4*G/A, and CTLA4*A/A between the patients with bipolar disorder and the control group (48.9% vs 46.3%, 44.4% vs 39.6%, and 6.7% vs 14.1%, respectively). There were no significant differences in allelic frequencies of CTLA4*G and CTLA4*A between the patients with bipolar disorder and the control group (71.1% vs 66.1%; 28.9% vs 33.9%, respectively). In the present study an association was not found of exon 1 (+49) polymorphism of CTLA4 gene with bipolar disorder in the Korean |
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| CTLA4 |
Genotypic P-value = 0.208, X<sup>2</sup>(df=2)=3.14; allelic P-value = 0.256, X<sup>2</sup>(df=1)=1.29 in patients with bipolar disorder compared with controls..
There were no significant differences in genotype frequencies of CTLA4*G/G, CTLA4*G/A, and CTLA4*A/A......
There were no significant differences in genotype frequencies of CTLA4*G/G, CTLA4*G/A, and CTLA4*A/A between the patients with bipolar disorder and the control group.There were no significant differences in allelic frequencies of CTLA4*G and CTLA4*A between the patients with bipolar disorder and the control group. In the present study an association was not found of exon 1 (+49) polymorphism of CTLA4 gene with bipolar disorder in the Korean population.
More...
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Negative
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