Study Report
Basic Info
| Reference |
Lachman, H. M., 2008 PMID: 18496207
|
| Citation |
Lachman, H. M., O. A. Petruolo, et al. (2008). "Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia." Psychiatr Genet 18(3): 110-115.
|
| Disease Type |
Bipolar Disorder & Schizophrenia |
| Study Design |
case-control |
| Study Type |
Mutational study |
| Sample Size |
Patients with BD (n=169); Patients with SZ (n=169); US controls (n=163) |
| SNP/Region/Marker Size |
1 variant |
| Predominant Ethnicity |
Caucasian |
| Population |
American and Czech |
Detail Info
| Sample Diagnosis |
DSM-IV; Mini International Neuropsychiatric Interview |
| Technique |
PCR amplification; genotyping |
| Statistical Method |
A statistical program, StatXACT-5 (Cytel Software Corporation, Cambridge, Massachusetts, USA) was used to compute the X2 and Fisher statistics. The level of significance was set at P<0.05. Hardy-Weinberg equilibrium was examined using a goodness-of-fit X2 test. |
| Result Summary |
No significant difference was observed in the frequency of the alpha8-alpha10_del variant in patients with SZ or BD compared with their respective controls. |
Genetic factors reported by this study for BD
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| alpha8-alpha10 del |
5q31-linked PCDH family |
insertion/deletion |
|
|
BD allele frequency X2=0.19, P-value = 0.66
|
No significant difference was observed in the frequency of t......
No significant difference was observed in the frequency of the alpha8-alpha10_del variant in patients with SZ or BD compared with their respective controls.
More...
|
Negative
|
Genetic factors reported by this study for SZ and/or MDD
Other variants reported by this study for SZ/MDD
