BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Masoliver, E., 2006 PMID: 16395126
Citation	Masoliver, E., A. Menoyo, et al. (2006). "Serotonin transporter linked promoter (polymorphism) in the serotonin transporter gene may be associated with antidepressant-induced mania in bipolar disorder." Psychiatr Genet 16(1): 25-29.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	103 outpatients with bipolar affective disorder, 85 outpatients with unipolar affective disorder and 101 matched controls
SNP/Region/Marker Size	2 variants
Predominant Ethnicity
Population	Spanish
Gender	66% women of BP group, 71% women of UP group
Age Group	adults : mean age 54.3 years, SD=16.6 of BP group, mean age 60.1 years, SD=12.5 of UP group

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	The participants undergoing investigation for the purpose of this study were recruited from their own sample of patients followed in the Lithium Therapy Clinic. In all, there were 103 outpatients with bipolar affective disorder (BP group), 85 outpatients with unipolar affective disorder (UP group).
Technique	genotyping using PCR
Statistical Method	All the statistical analyses were performed using SPSS for Windows version 11. The t-test for independent samples was used for the continuous variables, whereas the chi square test was employed for the dichotomous ones. The a level of significance used was set at P=0.05 (two-tailed), and was not adjusted for the main objective.
Result Summary	The association analysis performed showed a significantly higher rate of homozygous s/s genotype for 5-HTTLPR among patients with a history of antidepressant-induced mania (60% patients s/s versus 40% l/l, chi, P=0.04). No significant difference in the distribution of genotypes of the two polymorphisms was observed between the three groups. They found no significant association between these polymorphisms and lithium response. The 5-HTTLPR polymorphism could be a useful contributor, among other clinical variables, to predict the risk for manic switches when a patient with bipolar disorder is treated with antidepressant drugs. The contribution of these genetic markers in diagnosis expression and treatment response to lithium is likely to be minor.

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
SLC6A4 intron2 VNTR	SLC6A4	VNTR	10, 12 repeat		P-value = NS (not significant) of allele frequencies and distribution of genotypes in individuals with bipolar disorder, unipolar disorder and controls	No significant differences in the genotype distribution were...... No significant differences in the genotype distribution were observed. More...	Negative
5HTTLPR	SLC6A4	microsatellite	l/s		P-value = NS (not significant) of allele frequencies and distribution of genotypes in individuals with bipolar disorder, unipolar disorder and controls	No significant differences in the genotype distribution were...... No significant differences in the genotype distribution were observed. More...	Negative

Genes reported by this study for BD (count: 1)