BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Gutierrez, B.,2001 PMID: 11502363
Citation	Gutierrez, B., B. Arias, et al. (2001). "Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder." Neurosci Lett 309(2): 135-137.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	88 bipolar patients and 162 controls
SNP/Region/Marker Size	2 variants
Predominant Ethnicity
Population	Spanish
Gender	37 men and 51 women for bipolar patients;81 men and 81 women for control subjects

Detail Info

Sample Diagnosis	DSM
Sample Status	Eighty-eight patients with bipolar disorder consecutively admitted to the ClI?nica Mental Santa Coloma (Barcelona,Spain) between January 1993 and December 1995 were included in this study. The sample, previously described elsewhere, consisted of 37 men and 51 women who met disease criteria as defined by the Diagnostic and Statistical Manual, 3rd edition, revised (DSM-III-R).The control sample consisted of one hundred and sixtytwo healthy individuals (81 men and 81 women). Both,cases and controls were Spanish subjects of Spanish origin.Patients, their relatives and controls gave informed consent prior their inclusion in the study.
Technique	genotyping
Statistical Method	The presence of allele or genotype association was determined with the chi-squared test of independence.
Result Summary	Statistical analyses revealed no overall allele or genotype associations with the disease. A haplotype analyses between the (GT)12-18/(CT)4-5 motif and a Cys23Ser variant of the 5-HT2C gene (which had previously been genotyped in the same sample) showed similar distributions between cases and controls. Only a slight increase of s-Ser23 haplotype was found in the subgroup of bipolar women with family history of psychiatric illness (OR=1.24 [95%CI: 1.12-1.38]).

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
[HTR2C_GT(12-18)/CT(4-5)] - (HTR2C_Cys23Ser)		HTR2C	Haplotype analysis:chi sauqre test, allele P-value > 0.05	No significant association was observed in BD. No significant association was observed in BD.	Negative

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
HTR2C GT(12-18)/CT(4-5)	HTR2C	microsatellite	short/long		Association analysis:chi sauqre test, allele P-value > 0.05	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 1)