Study Report

Basic Info
Reference |
Gutierrez, B.,2001 PMID: 11502363
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Citation |
Gutierrez, B., B. Arias, et al. (2001). "Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder." Neurosci Lett 309(2): 135-137.
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Disease Type |
Bipolar Disorder |
Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
88 bipolar patients and 162 controls |
SNP/Region/Marker Size |
2 variants |
Predominant Ethnicity |
|
Population |
Spanish |
Gender |
37 men and 51 women for bipolar patients;81 men and 81 women for control subjects |

Detail Info
Sample Diagnosis |
DSM |
Sample Status |
Eighty-eight patients with bipolar disorder consecutively admitted to the ClI?nica Mental Santa Coloma (Barcelona,Spain) between January 1993 and December 1995 were included in this study. The sample, previously described elsewhere, consisted of 37 men and 51 women who met disease criteria as defined by the Diagnostic and Statistical Manual, 3rd edition, revised (DSM-III-R).The control sample consisted of one hundred and sixtytwo healthy individuals (81 men and 81 women). Both,cases and controls were Spanish subjects of Spanish origin.Patients, their relatives and controls gave informed consent prior their inclusion in the study. |
Technique |
genotyping |
Statistical Method |
The presence of allele or genotype association was determined with the chi-squared test of independence. |
Result Summary |
Statistical analyses revealed no overall allele or genotype associations with the disease. A haplotype analyses between the (GT)12-18/(CT)4-5 motif and a Cys23Ser variant of the 5-HT2C gene (which had previously been genotyped in the same sample) showed similar distributions between cases and controls. Only a slight increase of s-Ser23 haplotype was found in the subgroup of bipolar women with family history of psychiatric illness (OR=1.24 [95%CI: 1.12-1.38]). |

Haplotypes reported by this study for BD (count: 1)
Markers |
Haplotype |
Related Gene(s)/Region(s) |
Statistical Values |
Author Comments |
Result Category |
[HTR2C_GT(12-18)/CT(4-5)] - (HTR2C_Cys23Ser) |
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HTR2C
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Haplotype analysis:chi sauqre test, allele P-value > 0.05
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No significant association was observed in BD.
No significant association was observed in BD.
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Negative
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Other variants reported by this study for BD (count: 1)
Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
HTR2C GT(12-18)/CT(4-5) |
HTR2C |
microsatellite |
short/long |
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Association analysis:chi sauqre test, allele P-value > 0.05
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No significant association was observed in BD.
No significant association was observed in BD.
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Negative
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Genes reported by this study for BD (count: 1)
Gene |
Statistical Values/Author Comments |
Result Category |
HTR2C |
In summary, although the present results make it unlikelythat the 5-HT2C receptor gene plays an impo......
In summary, although the present results make it unlikelythat the 5-HT2C receptor gene plays an important role in bipolar disorder.
More...
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Negative
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