Study Report
Basic Info
| Reference |
Foroud, T.,2000 PMID: 10686547
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| Citation |
Foroud, T., P. F. Castelluccio, et al. (2000). "Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees." Am J Med Genet 96(1): 18-23.
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| Disease Type |
Bipolar Disorder & Schizophrenia |
| Study Design |
pedigree |
| Study Type |
Genome-wide linkage study |
| Sample Size |
97 families including 232 subjects diagnosed with bipolar I (BPI), 32 with schizo-affective, bipolar type (SABP), 72 with bipolar II (BPII), and 88 with unipolar recurrent depression (UPR). |
| SNP/Region/Marker Size |
a genome screen using 365 markers |
| Predominant Ethnicity |
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| Population |
NIMH collections |
Detail Info
| Statistical Method |
Linkage analysis was primarily focused on nonparametric affected relative pair methods since the results of affected sib pair analyses have been published previously [Edenberg et al., 1997; Detera-Wadleigh et al.,1997; Rice et al., 1997; Stine et al., 1997].A set of three hierarchical diagnoses was used in all analyses. Under Model I, an affected individual was one who was diagnosed with either SABP or BPI. Under Model II, affected individuals were those included with SABP, BPI, and BPII. Under Model III, affected individuals were those with SABP, BPI, and BPII, as well as UPR. |
| Result Summary |
The strongest finding was a lod score of 2.5 obtained on chromosome 10 near the marker D10S1423 with diagnosis as defined under Model II. This region has been previously implicated in genome-wide studies of schizophrenia and bipolar disorder. Other chromosomal regions with lod scores over 1.50 for at least one Model Included chromosomes 8 (Model III), 16 (Model III), and 20 (Model I). |
Regions reported by this study for BD (count: 4)
| Region |
Statistical Values |
Author Comments |
Result Category |
| Chr 20 |
Genome-Wide Linkage Results: LOD = 1.7 on Model I, LOD = 0.5 on Model II, LOD = 0.4 on Model III
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No significant linkage was found in this region.
No significant linkage was found in this region.
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Negative
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| Chr 16 |
Genome-Wide Linkage Results: LOD = 0.6 on Model I, LOD = 1.2 on Model II, LOD = 1.7 on Model III
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No significant linkage was found in this region.
No significant linkage was found in this region.
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Negative
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| Chr 8 |
Genome-Wide Linkage Results: LOD = 0.1 on Model I, LOD = 1.4 on Model II, LOD = 1.6 on Model III
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No significant linkage was found in this region.
No significant linkage was found in this region.
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Negative
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| Chr 10 |
Genome-Wide Linkage Results: LOD = 1.5 on Model I, LOD = 2.5 on Model II, LOD = 1.3 on Model III
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Suggestive linkage was found in this region.
Suggestive linkage was found in this region.
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Trend
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