Study Report

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Basic Info

Reference	Kelsoe, J. R.,2001 PMID: 11149935
Citation	Kelsoe, J. R., M. A. Spence, et al. (2001). "A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22." Proc Natl Acad Sci U S A 98(2): 585-590.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	pedigree
Study Type	Genome-wide linkage study
Sample Size	57 families including 345 subjects(169 with bipolar I disorder, 36 with bipolar II disorder, and 45 with recurrent major depression)
SNP/Region/Marker Size	443 microsatellite markers across whole genome wide
Predominant Ethnicity
Population	NIMH collections

Detail Info

Statistical Method	Linkage analyses were carried out using the parametric lod score approach to maximize power over the sample size available.
Result Summary	A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.

Regions reported by this study for BD (count: 30)

Region	Statistical Values	Author Comments	Result Category
13q31-q34	Linkage analysis: For marker D13S154, Two-point lod = 2.4, BP+RD, AR50; For marker D13S225, Two-point lod = 2.22, BPonly, AR50; For marker D13S796, Two-point lod = 2.34, BP+RD, AD85	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 10_156.27cM	Linkage analysis: Two-point lod = 2.27, BPonly, AR50	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 10_147.57cM	Linkage analysis: Two-point lod = 1.37, BPonly, AD50	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_16.4cM	Linkage analysis: Two-point lod = 0.83, BPonly, AR	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 10_157.89cM	Linkage analysis: Two-point lod = 1.74, BPonly, AR50	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
3p21	Linkage analysis: Two-point lod = 2.01, BPonly, AD85	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
21q22	Linkage analysis: Two-point lod = 2.04, BP+RD, AD50	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 10_134.7cM	Linkage analysis: Two-point lod = 1.11, BP+RD, AD85	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
3q27	Linkage analysis: Two-point lod = 2.66, BPonly, AD85	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 22_32.4cM	Linkage analysis: Two-point lod = 0.82, BPonly, AR	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_28.6cM	Linkage analysis: Two-point lod = 2.17, BPonly, AR	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 22_36.2cM	Linkage analysis: For marker D22S683, Two-point lod = 1.34, BP only, AR; For marker D22S278, Two-point lod = 1.58, BP+RD, AD	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_35.2cM	Linkage analysis: Two-point lod = 1.46, BPonly, AR	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_21.5cM	Linkage analysis: For marker D22S315, Two-point lod = 1.14, BPonly, AR; For marker D22S421, Two-point lod = 1.12, BPonly, AR; For marker D22S925, Two-point lod = 2.25, BPonly, AR; For marker D22S419, Two-point lod = 2.72, BPonly, AR	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 22_19.3cM	Linkage analysis: Two-point lod = 0.86, BPonly, AD	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_27.5cM	Linkage analysis: Two-point lod = 1.85, BPonly, AR	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_22cM	Linkage analysis: Two-point lod = 1.17, BPonly, AR	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_181.87cM	Linkage analysis: Two-point lod = 0.38, BPonly, AD85	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_188.29cM	Linkage analysis: Two-point lod = 1.18, BPonly, AD85	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_112.42cM	Linkage analysis: Two-point lod = 1.07, BPonly, AD50	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_119.09cM	Linkage analysis: Two-point lod = 0.25, BPonly, AD85	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_42.8cM	Linkage analysis: Two-point lod = 0.63, BPonly, AD	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_102.64cM	Linkage analysis: Two-point lod = 1.32, BPonly, AD85	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_38.6cM	Linkage analysis: Two-point lod = 1, BPonly, AR	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_41.4cM	Linkage analysis: Two-point lod = 0.28, BPonly, AR	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_78.64cM	Linkage analysis: Two-point lod = 1.4, BPonly, AD85	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_224.88cM	Linkage analysis: Two-point lod = 0.78, BPonly, AD50	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_70.61cM	Linkage analysis: Two-point lod = 0.74, BPonly, AR50	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_201.14cM	Linkage analysis: Two-point lod = 0.61, BPonly, AD85	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_215.84cM	Linkage analysis: Two-point lod = 1.41, BPonly, AR50	No significant linkage was found in this region. No significant linkage was found in this region.	Negative