Meta-analysis Report

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Basic Info

Reference	Segurado, R.,2003 PMID: 12802785
Citation	Segurado, R., S. D. Detera-Wadleigh, et al. (2003). "Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder." Am J Hum Genet 73(1): 49-62.
Disease Type	Bipolar Disorder
Study Type	Genome-wide linkage study

Detail Info

Samples	18 BPD genome scan data sets :Nine studies included linkage analyses consistent with our model 1, with a total of 347 pedigrees and 948 genotyped cases. Fourteen studies included linkage analyses consistent with model 2 (512 pedigrees, 1,733 cases). Among these 14 were 6 studies that had analyzed both models 1 and 2; 3 studies with only a model 1 analysis, which was therefore also included in our model 2; and 5 studies with an analysis under model 2 but not model 1.Secondary analyses were also performed under a'broad' disease model (model 3, adding recurrent major depressive disorder [MDD]; 593 pedigrees, 2,437 cases.
Statistic Method	The rank-based genome scan meta-analysis (GSMA) method was applied.The two primary analyses considered available linkage data for very narrow (i.e., BP-I and schizoaffective disorder-BP) and narrow (i.e., adding BP-II disorder) disease models, with the ranks weighted for sample size. A broad model (i.e., adding recurrent major depression) and unweighted analyses were also performed.
Basic Result	No region achieved genomewide statistical significance by several simulation-based criteria. The most significant P values (<.01) were observed on chromosomes 9p22.3-21.1 (very narrow), 10q11.21-22.1 (very narrow), and 14q24.1-32.12 (narrow). Nominally significant P values were observed in adjacent bins on chromosomes 9p and 18p-q, across all three disease models on chromosomes 14q and 18p-q, and across two models on chromosome 8q. The present results for the very narrow model are promising but suggest that more and larger data sets are needed. Alternatively, linkage might be detected in certain populations or subsets of pedigrees. The narrow and broad data sets had considerable power, according to simulation studies, but did not produce more highly significant evidence for linkage. We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region.

Regions reported by this study for BD (count: 21)

Region	Statistical Values	Author Comments	Result Category
5pter-p15.1	The rank-based genome scan meta-analysis: Unweighted P-value < 0.05(Model 2)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
3q22.1-q25.31	The rank-based genome scan meta-analysis: Unweighted P-value < 0.05(Model 2)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
2q22.1-q23.3	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 2); Unweighted P-value < 0.05(Model 2)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
21q21.3-qter	The rank-based genome scan meta-analysis: Unweighted P-value < 0.05(Model 2)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
20pter-p12.3	The rank-based genome scan meta-analysis: Unweighted P-value < 0.05(Model 3)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
1q31-q32	The rank-based genome scan meta-analysis: Unweighted P-value < 0.05(Model 2)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
1p32.1-q31.1	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 1); Unweighted P-value < 0.05(Model 1)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
19q13.33-qter	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 1); Unweighted P-value < 0.05(Model 1)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
9p22.3-p21.1	The rank-based genome scan meta-analysis: Weighted P-value < 0.01(Model 1); Unweighted P-value < 0.01(Model 1)	Suggestive linkage was found in this region(P-value < 0.01). Suggestive linkage was found in this region(P-value < 0.01).	Trend
9p21.1-q21.32	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 1)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
8q24.21-qter	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 2), P-value < 0.05(Model 3)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
8pter-p22	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 2); Unweighted P-value < 0.05(Model 2)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
7q34-qter	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 3)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
18pter-p11	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 1); Unweighted P-value < 0.05(Model 1)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
18q12.3-q22.1	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 3); Unweighted P-value < 0.05(Model 2), P-value < 0.05(Model 3)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
17p12-q21.33	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 1)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
18p11-q12.3	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 1), P-value < 0.05(Model 2), P-value < 0.05(Model 3); Unweighted P-value < 0.05(Model 2), P-value < 0.05(Model 3)	Suggestive linkage was found in this region under three diff...... Suggestive linkage was found in this region under three different diagnostic models. More...	Trend
14q13.1-q24.1	The rank-based genome scan meta-analysis: Unweighted P-value < 0.05(Model 2), P-value < 0.05(Model 3)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
14q24.1-q32.12	The rank-based genome scan meta-analysis: Weighted P-value < 0.05(Model 1), P-value < 0.01(Model 2), P-value < 0.01(Model 3); Unweighted P-value < 0.05(Model 2), P-value < 0.05(Model 3)	Suggestive linkage was found in this region under two differ...... Suggestive linkage was found in this region under two different diagnostic models. More...	Trend
10q11.21-q22.1	The rank-based genome scan meta-analysis: Weighted P-value < 0.01(Model 1); Unweighted P-value < 0.05(Model 1)	Suggestive linkage was found in this region(P-value < 0.01). Suggestive linkage was found in this region(P-value < 0.01).	Trend
11p13-q13.3	The rank-based genome scan meta-analysis: Unweighted P-value < 0.05(Model 3)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative