BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Ross, J.,2008 PMID: 18628681
Citation	Ross, J., W. Berrettini, et al. (2008). "Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20." Psychiatr Genet 18(4): 191-198.
Disease Type	Bipolar Disorder
Study Design	pedigree
Study Type	Genome-wide linkage study
Sample Size	644 bipolar families containing 1565 individuals
SNP/Region/Marker Size	whole genome wide
Predominant Ethnicity
Population	NIMH collections

Detail Info

Regions reported by this study for BD (count: 13)

Region	Statistical Values	Author Comments	Result Category
Chr 8_50.05cM	Linkage analysis: BPI-Rec model, theta = 0.3, two-point LOD = 1.57; UP-Dom model, theta = 0.3, two-point LOD = 1.77	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 6_147-153cM	Linkage analysis: BPII-Dom model, theta = 0.2, two-point LOD = 1.65	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 4_208.07cM	Linkage analysis: BPI-Rec model, theta = 0.2, two-point LOD = 1.67; BPI-Dom model, theta = 0.1, two-point LOD = 2.01	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 20_9.53cM	Linkage analysis: BPII-Rec model, theta = 0.3, two-point LOD = 1.6	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 1_97.72cM	Linkage analysis: UP-Dom model, theta = 0.2, two-point LOD = 1.87	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 20_24.7cM	Linkage analysis: BPII-Rec model, theta = 0.2, two-point LOD = 1.72	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 20_50.81cM	Linkage analysis: UP-Rec model, theta = 0.2, two-point LOD = 1.9	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 16_39.04cM	Linkage analysis: BPII-Dom model, theta = 0.2, two-point LOD = 1.57	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 20	Multipoint linkage analysis: BPII-Rec model, the highest multipoint score was 3.0	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 16	Multipoint linkage analysis: BPII-Dom model, the highest multipoint score was 4.91	Significant linkage was found in this region. Significant linkage was found in this region.	Positive
Chr 16_22.65cM	Linkage analysis: BPII-Dom model, theta = 0.3, two-point LOD = 3.29; UP-Dom model, theta = 0.3, two-point LOD = 1.97	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Chr 11_0cM	Linkage analysis: UP-Dom model, theta = 0.2, two-point LOD = 1.89	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 12_136.82cM	Linkage analysis: UP-Dom model, theta = 0.4, two-point LOD = 1.59	No significant linkage was found in this region. No significant linkage was found in this region.	Negative