Meta-analysis Report

Comment on Study

View All Comments on Study

Basic Info

Reference	McQueen, M. B.,2005 PMID: 16175504
Citation	McQueen, M. B., B. Devlin, et al. (2005). "Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q." Am J Hum Genet 77(4): 582-595.
Disease Type	Bipolar Disorder
Study Type	Genome-wide linkage study

Detail Info

Samples	We conducted a combined analysis using the original genotype data from 11 BP genomewide linkage scans comprising 5,179 individuals from 1,067 families.Two hierarchical definitions for BP affection status were used: (1) a narrow model that included individuals who received a diagnosis of BPI only and (2) a broad model that included individuals who received a diagnosis of either BPI or BPII. Relatives who received a diagnosis of disorders other than BPI or BPII were coded as 'unknown.'We have the original genotype data for 1,445 ARPs for the narrow phenotype definition and 2,272 ARPs for the broad phenotype definition. Note that families ascertained through non-BPI-affected probands but that met criteria for the BP broad phenotype model were included in the analysis (i.e., BPII-affected probands from UCSD).
Statistic Method	We used MERLIN's implementation of the Whittemore and Halpern (1994) algorithm to test for allele sharing among all affected individuals, and we generated the nonparametric LOD score via the Kong and Cox (1997) linear model. We also estimated the linkage information at each analysis position, using MERLIN's measure of entropy.The Q-statistic was utilized to provide a formal test of heterogeneity (Laird and Mosteller 1990).
Basic Result	Using the pooled data, we demonstrated genomewide significant linkage to chromosomes 6q and 8q and genomewide suggestive linkage to chromosomes 9p and 20p.In the region that encompasses the significant linkage signals on chromosome 6 and 8, there was no evidence of heterogeneity among data sets as tested via the Qstatistic(P <0.10).

Regions reported by this study for BD (count: 36)

Region	Statistical Values	Author Comments	Result Category
Chr 16_35cM	Pooled Analysis: for Broad BP, LOD = 0.85	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 17_98cM	Pooled Analysis: for Narrow BP, LOD = 1.36; for Broad BP, LOD = 0.91	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 15_25cM	Pooled Analysis: for Broad BP, LOD = 0.73	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 16_30cM	Pooled Analysis: for Narrow BP, LOD = 0.18	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 14_79cM	Pooled Analysis: for Narrow BP, LOD = 0.54; for Broad BP, LOD = 0.19	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 15_21cM	Pooled Analysis: for Narrow BP, LOD = 0.95	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 13_44cM	Pooled Analysis: for Narrow BP, LOD = 0.62	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 13_50cM	Pooled Analysis: for Broad BP, LOD = 0.46	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 11_72cM	Pooled Analysis: for Narrow BP, LOD = 0.54; for Broad BP, LOD = 0.57	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 12_155cM	Pooled Analysis: for Narrow BP, LOD = 0.4; for Broad BP, LOD = 0.13	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 10_50cM	Pooled Analysis: for Broad BP, LOD = 0.2	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 10_85cM	Pooled Analysis: for Narrow BP, LOD = 0.07	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 1_200cM	Pooled Analysis: for Narrow BP, LOD = 0.41	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 1_79cM	Pooled Analysis: for Broad BP, LOD = 0.59	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 9_46cM	Pooled Analysis: for Narrow BP, LOD = 2.04	There is a trend for Significant linkage in this region(Geno...... There is a trend for Significant linkage in this region(Genomewide suggestive:LOD > 1.75). More...	Trend
Chr 9_48cM	Pooled Analysis: for Broad BP, LOD = 2.06	There is a trend for Significant linkage in this region(Geno...... There is a trend for Significant linkage in this region(Genomewide suggestive:LOD > 1.75). More...	Trend
Chr 6_115cM	Pooled Analysis: for Narrow BP, LOD = 4.19; for Broad BP, LOD = 1.74	Significant linkage was found in this region(Genomewide sign...... Significant linkage was found in this region(Genomewide significant:LOD > 3.03). More...	Positive
Chr 7_187cM	Pooled Analysis: for Narrow BP, LOD = 0.57; for Broad BP, LOD = 0.7	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 8_151cM	Pooled Analysis: for Broad BP, LOD = 3.40	Significant linkage was found in this region(Genomewide sign...... Significant linkage was found in this region(Genomewide significant:LOD > 3.03). More...	Positive
Chr 8_152cM	Pooled Analysis: for Narrow BP, LOD = 1.99	There is a trend for Significant linkage in this region(Geno...... There is a trend for Significant linkage in this region(Genomewide suggestive:LOD > 1.75). More...	Trend
Chr 4_154cM	Pooled Analysis: for Broad BP, LOD = 0.56	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 4_152cM	Pooled Analysis: for Narrow BP, LOD = 0.39	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 5_79cM	Pooled Analysis: for Narrow BP, LOD = 0.31	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 5_78cM	Pooled Analysis: for Broad BP, LOD = 0.11	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_9cM	Pooled Analysis: for Broad BP, LOD = 0.03	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 22_2cM	Pooled Analysis: for Narrow BP, LOD = 0.12	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_69cM	Pooled Analysis: for Broad BP, LOD = 0.14	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 3_1cM	Pooled Analysis: for Narrow BP, LOD = 0.19	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 20_12cM	Pooled Analysis: for Broad BP, LOD = 1.71; for Narrow BP, LOD = 1.91	There is a trend for Significant linkage in this region(Geno...... There is a trend for Significant linkage in this region(Genomewide suggestive:LOD > 1.75). More...	Trend
Chr 2_92cM	Pooled Analysis: for Narrow BP, LOD = 0.97; for Broad BP, LOD = 1.1	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 21_60cM	Pooled Analysis: for Narrow BP, LOD = 0.06	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 21_48cM	Pooled Analysis: for Broad BP, LOD = 0.03	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 18_87cM	Pooled Analysis: for Broad BP, LOD = 1.05	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 18_70cM	Pooled Analysis: for Narrow BP, LOD = 1.47	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 19_73cM	Pooled Analysis: for Narrow BP, LOD = 0.33	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Chr 19_37cM	Pooled Analysis: for Broad BP, LOD = 0.13	No significant linkage was found in this region. No significant linkage was found in this region.	Negative