Study Report
Basic Info
| Reference |
Kerner, B.,2007 PMID: 16958032
|
| Citation |
Kerner, B., D. L. Brugman, et al. (2007). "Evidence of linkage to psychosis on chromosome 5q33-34 in pedigrees ascertained for bipolar disorder." Am J Med Genet B Neuropsychiatr Genet 144B(1): 74-78.
|
| Disease Type |
Bipolar I Disorder |
| Study Design |
pedigree |
| Study Type |
Genome-wide linkage study |
| Sample Size |
332 affected relative pairs in 138 families |
| SNP/Region/Marker Size |
460 microsatellite markers for one region |
| Predominant Ethnicity |
|
| Population |
NIMH collections(Waves 1, 3, and 4) |
Detail Info
| Statistical Method |
Non-parametric linkage analysis on affected relatives within the small nuclear families and moderately extended pedigrees of the NIMH-BPGI data sets was performed using the linkage package MENDEL, Version 6 [Lange et al., 2001]. |
| Result Summary |
This analysis identified a linkage signal on chromosome 5q33-q34, a region previously implicated in independent linkage studies of schizophrenia and of psychosis, broadly defined. This finding is consistent with the hypothesis that susceptibility to psychosis may characterize at least a subtype of bipolar disorder. |
Regions reported by this study for BD (count: 5)
| Region |
Statistical Values |
Author Comments |
Result Category |
| 13p11.1-13q13 |
linkage analysis: P-value = 0.003 in Waves 3/4
|
There is a trend for Significant linkage.
There is a trend for Significant linkage.
|
Trend
|
| 13q22-32 |
linkage analysis: P-value = 0.005 in Waves 1.
|
There is a trend for Significant linkage.
There is a trend for Significant linkage.
|
Trend
|
| 5q33-34 |
linkage analysis: P-value < 0.00001 in Waves 1.
|
Significant linkage was found in this region.
Significant linkage was found in this region.
|
Positive
|
| 6q21-22 |
linkage analysis: P-value = 0.005 in Waves 3/4.
|
There is a trend for Significant linkage.
There is a trend for Significant linkage.
|
Trend
|
| 8q21.2 |
linkage analysis: P-value = 0.002 in Waves 1.
|
There is a trend for Significant linkage.
There is a trend for Significant linkage.
|
Trend
|
