BDgene

Study Report

Basic Info
Reference
Citation Toyota, T., A. Watanabe, et al. (2000). "Association study on the DUSP6 gene, an affective disorder candidate gene on 12q23, performed by using fluorescence resonance energy transfer-based melting curve analysis on the LightCycler." Mol Psychiatry 5(5): 461, 489-494.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size Japanese unipolars (n = 132) and bipolars (n = 122), controls (n = 299)
SNP/Region/Marker Size 1 variant
Predominant Ethnicity Mongloid
Population Japanese
Gender The unipolar patients consisted of 52 males and 80 females.The bipolar patients consisted of 70 males and 52 females. The controls included 177 males and 122 females.
Age Group Adults : The unipolar patients: males (mean 56,SD=14 years), females(mean age 58,SD=13 years).The bipolar patients:males(mean 50,SD=13 years),females (mean 52,SD=12 years). Controls:males (mean 46,SD=10 years),females (mean 45,SD=15 years).

Detail Info

Genetic factors reported by this study for BD
Other variants reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
MDD DUSP6 Leu114Val DUSP6 point mutation Association analysis:chi square test, allele P-value = 0.43;genotype P-value = 0.44 No significant association was observed in MDD. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD DUSP6 No evidence for a significant disease-causing effect was found in Japanese unipolars (n = 132) and bipolars (n = 122), when compared with controls (n = 299). Negative