Study Report

Basic Info
Reference |
Toyota, T,2000 PMID: 11032376
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Citation |
Toyota, T., A. Watanabe, et al. (2000). "Association study on the DUSP6 gene, an affective disorder candidate gene on 12q23, performed by using fluorescence resonance energy transfer-based melting curve analysis on the LightCycler." Mol Psychiatry 5(5): 461, 489-494.
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Disease Type |
Bipolar Disorder & Major Depressive Disorder |
Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
Japanese unipolars (n = 132) and bipolars (n = 122), controls (n = 299) |
SNP/Region/Marker Size |
1 variant |
Predominant Ethnicity |
Mongloid |
Population |
Japanese |
Gender |
The unipolar patients consisted of 52 males and 80 females.The bipolar patients consisted of 70 males and 52 females. The controls included 177 males and 122 females. |
Age Group |
Adults
:
The unipolar patients: males (mean 56,SD=14 years), females(mean age 58,SD=13 years).The bipolar patients:males(mean 50,SD=13 years),females (mean 52,SD=12 years). Controls:males (mean 46,SD=10 years),females (mean 45,SD=15 years).
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Detail Info
Sample Diagnosis |
DSM |
Sample Status |
Mood disorder patients met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition (DSM-IV), and were diagnosed as either unipolar or bipolar by the consensus of at least two psychiatrists. They consisted of both outpatients and inpatients. About 30% of the unipolars had a single episode and the rest had recurrent episodes. Sixty per cent of the bipolars were diagnosed as bipolar I and 40% were bipolar II. Control subjects were recruited from hospital staff documented to be free of psychoses, and company employees who did not manifest psychiatric problems in brief interviews by psychiatrists. |
Technique |
PCR and RFLP |
Statistical Method |
chi-square tests |
Result Summary |
No evidence for a significant disease-causing effect was found in Japanese unipolars (n = 132) and bipolars (n = 122), when compared with controls (n = 299). More importantly, this study demonstrates that melting curve analysis on the LightCycler is an accurate, rapid and robust method for discriminating genotypes from biallelic markers. This strategy has the potential for use in high throughput scanning for and genotyping of single nucleotide polymorphisms (SNPs). |

Genetic factors reported by this study for BD

Genetic factors reported by this study for SZ and/or MDD