Gene Report

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Basic Info

Approved Symbol	TTC27
Symbol Alias	FLJ20272
Approved Name	tetratricopeptide repeat domain 27
Location	2p22.3
Position	chr2:32628032-32821051, 1
External Links	HGNC: 25986 Entrez Gene: 55622 Ensembl: ENSG00000018699 UCSC: uc002rom.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs3769583	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005575	cellular_component	cellular component	ND	19
GO:0003674	molecular_function	molecular function	ND	24
GO:0008150	biological_process	biological process	ND	24

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TTC27	ACVR1	NO	in vivo	15761153
TTC27	BMPR1B	NO	in vivo	15761153
TTC27	TGFBR1	NO	in vivo	15761153

Related other genetic factors

Gene related SNPs (count: 14)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3769583	chr2:32743054 - 32743054(1)	intron_variant; NMD_transcript_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs971511	chr2:32750955 - 32750955(1)	intron_variant; NMD_transcript_variant
rs3769581	chr2:32744049 - 32744049(1)	intron_variant; NMD_transcript_variant
rs3769572	chr2:32757197 - 32757197(1)	intron_variant; NMD_transcript_variant
rs3769575	chr2:32752496 - 32752496(1)	intron_variant; NMD_transcript_variant
rs2057347	chr2:32767869 - 32767869(1)	intron_variant; NMD_transcript_variant
rs4952291	chr2:32761710 - 32761710(1)	intron_variant; NMD_transcript_variant
rs13020184	chr2:32774896 - 32774896(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs17012239	chr2:32770756 - 32770756(1)	intron_variant; NMD_transcript_variant
rs4952282	chr2:32688540 - 32688540(1)	intron_variant; NMD_transcript_variant
rs3931462	chr2:32783443 - 32783443(1)	intron_variant; NMD_transcript_variant
rs6710617	chr2:32758900 - 32758900(1)	intron_variant; NMD_transcript_variant
rs4952286	chr2:32739186 - 32739186(1)	intron_variant; NMD_transcript_variant
rs2057345	chr2:32732474 - 32732474(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p22.3	chr2:31800000-36300000	1 (0/1/0)
2p22	chr2:31800000-41500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:32628032..32821051 View in gBrowse