Gene Report

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Basic Info

Approved Symbol	TDRD7
Symbol Alias	PCTAIRE2BP
Approved Name	tudor domain containing 7
Location	9q22.33
Position	chr9:97411950-97496125, 1
External Links	HGNC: 30831 Entrez Gene: 23424 Ensembl: ENSG00000196116 UCSC: uc004axj.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.07. Encodes a component of cytoplasmic RNA granules which acts by binding to specific mRNAs and regulating their translation.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043186	P granule	cellular component	IEA	2
GO:0047485	protein N-terminus binding	molecular function	IEA	12
GO:0002089	lens morphogenesis in camera-type eye	biological process	IMP[21436445]	1
GO:0007283	spermatogenesis	biological process	ISS	29
GO:0007281	germ cell development	biological process	IEA	5
GO:0070306	lens fiber cell differentiation	biological process	IMP[21436445]	2
GO:0005515	protein binding	molecular function	IPI[14603251]	563
GO:0010608	posttranscriptional regulation of gene expression	biological process	IMP[21436445]	3
GO:0005737	cytoplasm	cellular component	ISS	322
GO:0033391	chromatoid body	cellular component	ISS	3
GO:0003729	mRNA binding	molecular function	IDA[21436445]	5
GO:0005759	mitochondrial matrix	cellular component	IEA	11
GO:0035770	ribonucleoprotein granule	cellular component	IDA[21436445]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TDRD7	ATXN2	YES	yeast 2-hybrid	16713569
TDRD7	TACC1	NO	in vitro;in vivo;yeast 2-hybrid	14603251
TDRD7	CDK17	NO	in vitro;in vivo;yeast 2-hybrid	10727952
TDRD7	GABPB1	NO	yeast 2-hybrid	16189514
TDRD7	CABLES1	NO	in vitro;in vivo;yeast 2-hybrid	11527406

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
9q21-32	chr9:65000000-114900000	1 (0/1/0)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q21-22	chr9:65000000-99800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr9:97411950..97496125 View in gBrowse