Gene Report

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Basic Info

Approved Symbol	RIN2
Symbol Alias	RASSF4
Approved Name	Ras and Rab interactor 2
Location	20p11.22
Position	chr20:19886521-20002457, 1
External Links	HGNC: 18750 Entrez Gene: 54453 Ensembl: ENSG00000132669 UCSC: uc002wro.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2009	SNP: rs6046396	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007264	small GTPase mediated signal transduction	biological process	NAS[1849280]	18
GO:0043547	positive regulation of GTPase activity	biological process	IEA; NAS[11733506]	30
GO:0005575	cellular_component	cellular component	ND	19
GO:0030695	GTPase regulator activity	molecular function	NAS[1849280]	1
GO:0017112	Rab guanyl-nucleotide exchange factor activity	molecular function	NAS[11733506]	1
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0006897	endocytosis	biological process	IEA	15
GO:0050790	regulation of catalytic activity	biological process	NAS[1849280]	11
GO:0005096	GTPase activator activity	molecular function	IEA	19

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RIN2	RAB5C	NO	yeast 2-hybrid	12972505
RIN2	BIN1	NO	in vitro	12972505
RIN2	RAB5B	NO	in vitro;yeast 2-hybrid	11733506
RIN2	RAB5A	NO	yeast 2-hybrid	12972505

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6046396	chr20:19871859 - 19871859(1)	upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:19886521..20002457 View in gBrowse