Gene Report

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Basic Info

Approved Symbol	RCAN2
Previous Symbol	DSCR1L1
Symbol Alias	ZAKI-4
Approved Name	regulator of calcineurin 2
Previous Name	Down syndrome critical region gene 1-like 1
Location	6p12.3
Position	chr6:46220736-46491972, -1
External Links	HGNC: 3041 Entrez Gene: 10231 Ensembl: ENSG00000172348 UCSC: uc003oyc.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Djurovic, S.,2010	SNP: rs13216050, rs4714904	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000166	nucleotide binding	molecular function	IEA	17
GO:0007614	short-term memory	biological process	IEA	5
GO:0005575	cellular_component	cellular component	ND	19
GO:0031987	locomotion involved in locomotory behavior	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IBA	322
GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity	molecular function	IBA	1
GO:0070884	regulation of calcineurin-NFAT signaling cascade	biological process	IBA	1
GO:0050790	regulation of catalytic activity	biological process	IBA	11
GO:0006979	response to oxidative stress	biological process	IEA	11
GO:0033173	calcineurin-NFAT signaling cascade	biological process	IEA	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RCAN2	PPP3CA	NO	in vitro;in vivo;yeast 2-hybrid	10861295 , 12102656

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs13216050	chr6:46190316 - 46190316(1)		1(0/1/0)
rs4714904	chr6:46185924 - 46185924(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6p12-q13	chr6:46200000-75200000	1 (0/1/0)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p12.3	chr6:46200000-51800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:46220736..46491972 View in gBrowse