Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	NCKAP5
Symbol Alias	NAP5, ERIH1, ERIH2
Approved Name	NCK-associated protein 5
Name Alias	Nck associated protein 5, "peripheral clock protein"
Location	2q21.2
Position	chr2:132671799-133568463, -1
External Links	HGNC: 29847 Entrez Gene: 344148 Ensembl: ENSG00000176771 UCSC: uc002ttp.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2009	SNP: rs10193871	For the EA sample, single-nucleotide polymorphisms (SNPs) with the strongest statistical evidence for association included rs5907577 in an intergenic region at Xq27.1 (P=1.6E-06) and rs10193871 in NAP5 at 2q21.2 (P=9.8E-06).	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005575	cellular_component	cellular component	ND	19
GO:0008150	biological_process	biological process	ND	24

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NCKAP5	NCK1	NO	yeast 2-hybrid	9344857

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10193871	chr2:133259481 - 133259481(1)	intron_variant	1(0/0/1)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_41	chr2:133734967-133872725 (Affymetrix SNP 6.0 array reference genome)	137758		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr2:132671799..133568463 View in gBrowse