Gene Report

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Basic Info

Approved Symbol	MED12L
Symbol Alias	KIAA1635, TNRC11L, TRALPUSH, TRALP
Approved Name	mediator complex subunit 12-like
Previous Name	mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)-like
Location	3q25.1
Position	chr3:151085697-151437072, 1
External Links	HGNC: 16050 Entrez Gene: 116931 Ensembl: ENSG00000144893 UCSC: uc003eyp.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008013	beta-catenin binding	molecular function	IEA	14
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IBA	91
GO:0016592	mediator complex	cellular component	IBA	5
GO:0006366	transcription from RNA polymerase II promoter	biological process	IBA; IEA	31
GO:0001104	RNA polymerase II transcription cofactor activity	molecular function	IBA	4
GO:0008134	transcription factor binding	molecular function	IEA	28

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_3	chr3:152495187-152534813 (NCBI Build 36/hg18)	40000	3q25.1	deletion

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q22.1-q25.31	chr3:129500000-157300000	1 (0/1/0)
3q25	chr3:149200000-161000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:151085697..151437072 View in gBrowse