Gene Report

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Basic Info

Approved Symbol	CARD16
Symbol Alias	COP1, COP, PSEUDO-ICE
Approved Name	caspase recruitment domain family, member 16
Location	11q23
Position	chr11:105041326-105101431, -1
External Links	HGNC: 33701 Entrez Gene: 114769 Ensembl: ENSG00000204397
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: CARD16_Chr11:104916205_A/G	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004869	cysteine-type endopeptidase inhibitor activity	molecular function	IEA	1
GO:0010951	negative regulation of endopeptidase activity	biological process	IEA	10
GO:0042981	regulation of apoptotic process	biological process	IEA	10

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CARD16	CARD17	NO	in vitro;in vivo	15383541
CARD16	CARD8	NO	in vitro;in vivo	11821383
CARD16	RIPK2	NO	in vivo	11432859 , 11536016

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
CARD16_Chr11:104916205_A/G	Upstream	Chr11:104916205	1 (0/0/1)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
11q22.3-11q23	chr11:102900000-121200000	2 (0/2/0)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q22-q23	chr11:97200000-121200000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
20479761	The results strongly implicate increased apoptotic stress in the samples from the MDD group. Three anti-apoptotic factors, Y-box-binding protein 1, caspase-1 dominant-negative inhibitor pseudo-ICE, and the putative apoptosis inhibitor FKGS2, were over-expressed	Pos	CARD16

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Region: chr11:105041326..105101431 View in gBrowse