BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	SLC6A3 -67A/T
Type	point mutation
Related Gene	SLC6A3
No. of Study	2 (Positive: 2; Negative 0; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Variant related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Keikhaee, M. R.,2005	A/T	T	Genotypic association:for case-control, X²=10.3, df=2, P-value < =0.006, OR=2.15(95% CI 1.34-3.47);for male case-control, X²=18.92, P-value < =0.001;for female case-control, Allelic association:T-allele:for case-control, X²=8.56, df=1, P-value < =0.003;for male case-control, X²=19.02, P-value < =0.001.	Significant associations were found in BD patients and in ma..... More Significant associations were found in BD patients and in male patients. Less	Positive
Ohadi, M., 2007	A/T		chi-square P-value = 0.001, OR=1.913 (95% CI, 1.3-2.81), X²=11.009, df=1 for TT/AT vs. AA; P-value = 0.007, OR=1.456 (95% CI, 1.108-1.913), X²=7.304, df=1 for T- vs. A- allele; P-value = 0.003, OR=3.624 (95%CI, 1.48-3.84), X²=8.825, df=1 for TT vs. AT and AA genotypes between male and female patients; genotypic P-value = 0.0001, X²=19.224, df=2; P-value = 0.003, OR=3.592 (95% CI, 1.47-3.77), X²=8.688, df=1 for TT vs. AT/AA between male cases and controls; P-value = 0.0001, OR=2.323 (95%CI, 1.58-3.41), X²=18.725, df=1 between the DAT1 -67 T allele and bipolar disorder in the male patients	There appeared to be a trend towards increased heterozygosit..... More There appeared to be a trend towards increased heterozygosity of female cases compared with controls; significant difference was observed between the cases and controls at the genotype and allele frequency levels; male cases and controls were significantly different at the genotype level; significant association was observed between the DAT1 -67 T allele and bipolar disorder in the male patients Less	Positive

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)