BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Debnath, M.,2012 PMID: 23246584
Citation	Debnath, M., et al. (2012). "The HLA-G low expressor genotype is associated with protection against bipolar disorder." Hum Immunol.
Disease Type	bipolar disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	561 BD patients and 161 healthy controls
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity	Caucasian
Population	French
Gender	42% male and 58% female cases, 62% male and 38% female controls
Age Group	adults : the mean age of the patient cohort is 22 years (range: 16-67); the mean age of the controls is 43 years (range: 19-64)

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Five hundred and sixty-one BD patients meeting DSM-IV criteria for BD (type I or II), consecutively admitted to three French university-affiliated psychiatry departments were interviewed by trained psychiatrists, using the French version of the Diagnostic Interview for Genetic Studies (DIGS version 3.0). All patients were euthymic at inclusion (i.e. having a Montgomery-Asberg depression rating scale score and a mania rating scale score no more than five.
Technique	PCR amplification and genotyping
Statistical Method	Comparisons of genotype and allele frequencies between patients and controls were performed using the Chi-square testing with Yate's correction or Fisher exact test whenever appropriate. p values (two tailed) were corrected (pc) using the Bonferroni method and findings considered statistically significant for pc equal or less than 0.05. Odds ratio (OR) and confidence interval 95% (CI95%) were calculated to assess the relative risk conferred by a specific allele or genotype. Deviation from Hardy-Weinberg equilibrium was analyzed using X2 testing.
Result Summary	Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc = 0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc = 0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs66554220	HLA-G				HLA-G 14bp Ins/Ins vs. other genotypes: 22% vs. 14%, in controls and patients respectively,p = 0.016, pc = 0.032; OR = 0.58, CI95% = 0.38â€“0.93	The analysis of the HLA-G 14bp genotype distribution reveale...... The analysis of the HLA-G 14bp genotype distribution revealed that the homozygous state of 14bp Ins allele was significantly more prevalent in healthy controls than in BD patients. More...	Positive

Genes reported by this study for BD (count: 1)