BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Mynett-Johnson, L., 1998 PMID: 9646882
Citation	Mynett-Johnson, L., V. Murphy, et al. (1998). "Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3)." Biol Psychiatry 44(1): 47-51.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	85 unrelated bipolar patients and 85 controls
SNP/Region/Marker Size	1 polymorphism
Predominant Ethnicity	Caucasian
Population	Irish
Gender	57.6% male cases, 42.4% female cases, 57.6% male controls, 42.4% female controls
Age Group	adults : cases: 22-81 years, mean age=47.5, SD=13.3; controls: 22-66 years, mean age=45.9, SD=11.2

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	The sample of 85 unrelated bipolar patients was identified at the Mood Disorder Clinic at St. Patrick's Hospital, Dublin. All of these cases were of Irish origin and were consecutive attenders at the clinic, which specializes in bipolar disorder. Diagnoses were based on Schedule for Affective Disorders and Schizophrenia-Lifetime (SADS-LB) interviews and case notes, and all cases met DSM-IV criteria for bipolar I.
Technique	genotyping
Statistical Method	chi-square test
Result Summary	There was evidence for an overall allelic association between the disease and a dinucleotide polymorphism within the ATP1A3 gene (p = .022). Subjects were then analyzed on the basis of a number of criteria, and the significance of the association increased when cases were divided based on the nature of the first episode. Patients who presented with a depressive episode first showed a significant association (p = .001) with this polymorphism. The results presented here provide preliminary evidence of an association between bipolar disorder and an alpha subunit of Na+, K+ ATPase, the expression of which predominates in the brain.

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
ATP1A3 2-7 allele	ATP1A3	others			Chi-square test, X²=13.19, df 5, P-value=0.022	There was significant allelic association overall, comparing...... There was significant allelic association overall, comparing 170 case alleles with 170 control alleles. More...	Positive

Genes reported by this study for BD (count: 1)