Study Report

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Basic Info

Reference	Sheng, G.,2012 PMID: 22309971
Citation	Sheng, G., M. Demers, et al. (2012). "Differences in the Circuitry-Based Association of Copy Numbers and Gene Expression Between the Hippocampi of Patients With Schizophrenia and the Hippocampi of Patients With Bipolar Disorder." Arch Gen Psychiatry.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene CNV study
Sample Size	A total of 15 patients with schizophrenia, 15 patients with bipolar disorder, and 15 healthy controls.
SNP/Region/Marker Size	28 target genes
Predominant Ethnicity
Population	American

Detail Info

Sample Diagnosis	DSM
Sample Status	For the analyses of copy number intensities, postmortem samples of hippocampi from 15 healthy controls, 15 patients with schizophrenia,and 15 patients with bipolar disorder were obtained from the Harvard Brain Tissue Resource Center at McLean Hospital in Belmont, Massachusetts.
Technique	Genotyping
Statistical Method	Fisher exact test.
Result Summary	The copy number intensities examined using both microarrays and quantitative real-time polymerase chain reaction for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. Other genes associated with GAD67 regulation also showed changes in copy number intensities, and these changes were similar in magnitude and direction to those previously reported for mRNA fold changes in sector CA3/2 but not sector CA1. Moreover, the copy number intensities and mRNA fold changes were significantly correlated for both patients with schizophrenia (r = 0.649; P = .0003) and patients with bipolar disorder (r = 0.772; P = .0002) in sector CA3/2 but not in sector CA1. CONCLUSION: Insertions and deletions of genomic DNA in gamma-aminobutyric acid cells at a key locus of the hippocampal circuit are reflected in transcriptional changes in GAD67 regulation that are circuitry-based and diagnosis-specific.

CNVs reported by this study for BD (count: 28)

Name	Position	Author Comments
CNV_Sheng[2012]_1	chr2:171362909-171670922	The Fisher exact test:for Sector CA3/2,P-value<.001;for Sector CA1,P-value=0.004. The copy number in...... The Fisher exact test:for Sector CA3/2,P-value<.001;for Sector CA1,P-value=0.004. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_2	chr10:26552050-26618469	The Fisher exact test:for Sector CA3/2,P-value=0.001;for Sector CA1,P-value>.05. The copy number int...... The Fisher exact test:for Sector CA3/2,P-value=0.001;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_3	chr21:29831916-30234289	The Fisher exact test:for Sector CA3/2,P-value=0.04;for Sector CA1,P-value>.05. The copy number inte...... The Fisher exact test:for Sector CA3/2,P-value=0.04;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_4	chr6:101957419-102622143	The Fisher exact test:for Sector CA3/2,P-value=0.04;for Sector CA1,P-value=0.02. The copy number int...... The Fisher exact test:for Sector CA3/2,P-value=0.04;for Sector CA1,P-value=0.02. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_5	chr1:37006017-37299068	The Fisher exact test:for Sector CA3/2,P-value=0.04;for Sector CA1,P-value>.05. The copy number inte...... The Fisher exact test:for Sector CA3/2,P-value=0.04;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_6	chr6:33362643-33432505	The Fisher exact test:for Sector CA3/2,P-value=0.004;for Sector CA1,P-value=0.004. The copy number i...... The Fisher exact test:for Sector CA3/2,P-value=0.004;for Sector CA1,P-value=0.004. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_8	chr4:109114461-109203182	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value=0.03. The copy number inte...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value=0.03. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_7	chr6:45427854-45614100	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_10	chr12:4259419-4276065	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_9	chr9:36843677-36871493	The Fisher exact test:for Sector CA3/2,P-value=0.006;for Sector CA1,P-value>.05. The copy number int...... The Fisher exact test:for Sector CA3/2,P-value=0.006;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_12	chr1:216594710-216680962	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_11	chr3:13498010-13519073	The Fisher exact test:for Sector CA3/2,P-value<.001;for Sector CA1,P-value<.001. The copy number int...... The Fisher exact test:for Sector CA3/2,P-value<.001;for Sector CA1,P-value<.001. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_14	chr18:46816802-46848896	The Fisher exact test:for Sector CA3/2,P-value=0.05;for Sector CA1,P-value=0.02. The copy number int...... The Fisher exact test:for Sector CA3/2,P-value=0.05;for Sector CA1,P-value=0.02. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_13	chr9:100911984-100954694	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value=0.02. The copy number inte...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value=0.02. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_16	chr13:21161875-21174668	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_15	chr11:69336099-69338136	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_18	chr8:31618950-32715614	The Fisher exact test:for Sector CA3/2,P-value<.0001;for Sector CA1,P-value=0.006. The copy number i...... The Fisher exact test:for Sector CA3/2,P-value<.0001;for Sector CA1,P-value=0.006. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_17	chr6:43850604-43854388	The Fisher exact test:for Sector CA3/2,P-value=0.02;for Sector CA1,P-value>.05. The copy number inte...... The Fisher exact test:for Sector CA3/2,P-value=0.02;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_20	chr17:38450800-38523755	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value=0.05. The copy number inte...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value=0.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_19	chr6:20509888-20598369	The Fisher exact test:for Sector CA3/2,P-value=0.04;for Sector CA1,P-value>.05. The copy number inte...... The Fisher exact test:for Sector CA3/2,P-value=0.04;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_22	chr17:7518132-7532486	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_21	chr3:130631711-130642529	The Fisher exact test:for Sector CA3/2,P-value=0.002;for Sector CA1,P-value>.05. The copy number int...... The Fisher exact test:for Sector CA3/2,P-value=0.002;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_25	chr17:59909735-59923805	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_26	chr18:50049273-50068773	The Fisher exact test:for Sector CA3/2,P-value=0.002;for Sector CA1,P-value>.05. The copy number int...... The Fisher exact test:for Sector CA3/2,P-value=0.002;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_23	chr12:120242043-120270178	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value=0.002. The copy number int...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value=0.002. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_24	chr19:55584616-55605773	The Fisher exact test:for Sector CA3/2,P-value=0.02;for Sector CA1,P-value>.05. The copy number inte...... The Fisher exact test:for Sector CA3/2,P-value=0.02;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_27	chr10:103330169-103412748	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...
CNV_Sheng[2012]_28	chr7:7642868-7725084	The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number inten...... The Fisher exact test:for Sector CA3/2,P-value>.05;for Sector CA1,P-value>.05. The copy number intensities for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. More...