BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Xu, C., 2008 PMID: 18199248
Citation	Xu, C., P. P. Li, et al. (2008). "Further support for association of the mitochondrial complex I subunit gene NDUFV2 with bipolar disorder." Bipolar Disord 10(1): 105-110.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	178 BD (the diagnoses of BD I = 124 or BD II= 54) and 120 controls
SNP/Region/Marker Size	6 SNPs
Predominant Ethnicity	Caucasian
Population	European

Detail Info

SNPs reported by this study for BD (count: 6)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs11661859	NDUFV2			not given in the original text	No statistically significant association was found between B...... No statistically significant association was found between BD and this SNP of the NDUFV2 gene examined here. More...	Negative
rs1156044	NDUFV2		A	Genotypic P-value = 0.000012, Bonferroni corrected genotypic P-value = 0.00007, Allelic P-value = 0.0020, Bonferroni corrected allelic P-value = 0.0130, OR (95% CI)=2.44 (1.36-4.36) . X²=9.39	The A allele of the NDUFV2 SNP rs1156044 was significantly a...... The A allele of the NDUFV2 SNP rs1156044 was significantly associated (Bonferroni-corrected) with BD but differed in allele (rs1156044 G allele) from that previously reported as associated with BD. More...	Positive
rs12454936	ANKRD12 NDUFV2			not given in the original text	No statistically significant association was found between B...... No statistically significant association was found between BD and this SNP of the NDUFV2 gene examined here. More...	Negative
rs11872481	NDUFV2			not given in the original text	No statistically significant association was found between B...... No statistically significant association was found between BD and this SNP of the NDUFV2 gene examined here. More...	Negative
rs977581	NDUFV2			Genotypic P-value = 0.1650; Allelic P-value = 0.0440, OR (95% CI)=1.59 (1.01-2.52). X²=4.04	Statistically significant allelic association of SNP rs97758...... Statistically significant allelic association of SNP rs977581 with BD and BD I was also detected, but significance was not retained after Bonferroni correction. More...	Positive
rs2279992	NDUFV2			not given in the original text	No statistically significant association was found between B...... No statistically significant association was found between BD and this SNP of the NDUFV2 gene examined here. More...	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
NDUFV2	Statistically significant increased frequency of allele A of the SNP rs1156044 was observed in the BD group as a whole [84.7%; odds ratio (OR) = 2.44, p = 0.013) and in the BD I subgroup (85.3%; OR = 2.55, p = 0.014), compared to healthy controls (69.4%).. While genetic variants of NDUFV2 may increase risk for BD, the role of its altered expression and th...... While genetic variants of NDUFV2 may increase risk for BD, the role of its altered expression and the link to intracellular Ca<sup>2+</sup> abnormalities in BD remains equivocal. More...	Positive