BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Lohoff, F. W., 2008 (a) PMID: 18349695
Citation	Lohoff, F. W., P. J. Bloch, et al. (2008). "Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder." Psychiatr Genet 18(2): 53-58.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	570 BD and 710 controls
SNP/Region/Marker Size	7 SNPs
Predominant Ethnicity	Caucasian
Population	European form NIMH collection

Detail Info

SNPs reported by this study for BD (count: 7)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs1610037	ADCYAP1	A/G		Genotypic P-value = 0.937, allelic P-value = 0.931 for BD when compared with controls	No statistically significant association was found between B...... No statistically significant association was found between BPD and controls for any of the SNPs on the genotypic or allelic level. More...	Negative
rs2846811	ADCYAP1	A/G		Genotypic P-value = 0.629, allelic P-value = 0.902 for BD when compared with controls	No statistically significant association was found between B...... No statistically significant association was found between BPD and controls for any of the SNPs on the genotypic or allelic level. More...	Negative
rs2856966	ADCYAP1	A/G		Genotypic P-value = 0.681, allelic P-value = 0.373 for BD when compared with controls	No statistically significant association was found between B...... No statistically significant association was found between BPD and controls for any of the SNPs on the genotypic or allelic level. More...	Negative
rs1893154	ADCYAP1	C/T		Genotypic P-value = 0.092, allelic P-value = 0.173 for BD when compared with controls	No statistically significant association was found between B...... No statistically significant association was found between BPD and controls for any of the SNPs on the genotypic or allelic level. More...	Negative
rs2231187	ADCYAP1	A/G		Genotypic P-value = 0.828, allelic P-value = 0.731 for BD when compared with controls	No statistically significant association was found between B...... No statistically significant association was found between BPD and controls for any of the SNPs on the genotypic or allelic level. More...	Negative
rs8192595	ADCYAP1	A/G		Genotypic P-value = 0.958, allelic P-value = 0.791 for BD when compared with controls	No statistically significant association was found between B...... No statistically significant association was found between BPD and controls for any of the SNPs on the genotypic or allelic level. More...	Negative
rs928978	ADCYAP1	C/A		Genotypic P-value = 0.192, allelic P-value = 0.644 for BD when compared with controls	No statistically significant association was found between B...... No statistically significant association was found between BPD and controls for any of the SNPs on the genotypic or allelic level. More...	Negative

Haplotypes reported by this study for BD (count: 18)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs1893154 - rs2846811 - rs8192595	2-1-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.08, X<sup>2</sup>=0.02, P-value =0.884	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs1893154 - rs2846811 - rs8192595	1-2-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.82, X<sup>2</sup>=2.06, P-value =0.151	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs1893154 - rs2846811 - rs8192595	1-1-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1, X<sup>2</sup>=0.98, P-value =0.321	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs2856966 - rs928978 - rs2231187	1-1-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1, X<sup>2</sup>=0.06, P-value =0.793	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs2846811 - rs8192595 - rs2856966	2-1-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.11, X<sup>2</sup>=0.12, P-value =0.729	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs2846811 - rs8192595 - rs2856966	1-1-2 (1=major allele, 2=minor allele)	ADCYAP1	OR=0.92, X<sup>2</sup>=0.14, P-value =0.707	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs2846811 - rs8192595 - rs2856966	1-1-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1, X<sup>2</sup>=0.01, P-value =0.943	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs2856966 - rs928978 - rs2231187	1-1-2 (1=major allele, 2=minor allele)	ADCYAP1	OR=0.99, X<sup>2</sup>=0.01, P-value =0.896	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs2856966 - rs928978 - rs2231187	1-2-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.29, X<sup>2</sup>=1, P-value =0.315	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs2856966 - rs928978 - rs2231187	2-2-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=0.6, X<sup>2</sup>=2.18, P-value =0.139	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs8192595 - rs2856966 - rs928978	1-1-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1, X<sup>2</sup>=0.48, P-value =0.487	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs8192595 - rs2856966 - rs928978	1-1-2 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.14, X<sup>2</sup>=0.23, P-value =0.625	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs8192595 - rs2856966 - rs928978	1-2-2 (1=major allele, 2=minor allele)	ADCYAP1	OR=0.65, X<sup>2</sup>=1.96, P-value =0.161	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs928978 - rs2231187 - rs1610037	1-1-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1, X<sup>2</sup>=1.38, P-value =0.24	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs928978 - rs2231187 - rs1610037	1-1-2 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.75, X<sup>2</sup>=0.44, P-value =0.503	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs928978 - rs2231187 - rs1610037	1-2-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.33, X<sup>2</sup>=0.23, P-value =0.626	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs928978 - rs2231187 - rs1610037	2-1-1 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.3, X<sup>2</sup>=0.1, P-value =0.746	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative
rs928978 - rs2231187 - rs1610037	2-1-2 (1=major allele, 2=minor allele)	ADCYAP1	OR=1.25, X<sup>2</sup>=0.01, P-value =0.917	Haplotype analysis did not show any significant association ...... Haplotype analysis did not show any significant association with disease. More...	Negative

Genes reported by this study for BD (count: 1)