Study Report
Basic Info
| Reference |
Ferreira, M. A.,2008 PMID: 18711365
|
| Citation |
Ferreira, M. A., M. C. O'Donovan, et al. (2008). "Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder." Nat Genet 40(9): 1056-1058.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Genome-wide association study |
| Sample Size |
4,387 cases and 6,209 controls |
| SNP/Region/Marker Size |
1.8 million variants |
| Predominant Ethnicity |
|
| Population |
WTCCC, STEP-UCL and ED-DUB-STEP2 studies |
Detail Info
| Technique |
genotyping |
| Statistical Method |
SNPs were tested for association using logistic regression co-varying for sample collection site and quantitative indices of ancestry based on a multi-dimensional scaling analysis; the genomic inflation factor was Lambda1,000 = 1.056 |
| Result Summary |
We identified a region of strong association (rs10994336, P = 9.1E9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7E-8, rs1006737). |
SNPs reported by this study for BD (count: 6)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs1938526 |
ANK3
|
|
G |
Genotyped P value=1.3E-08, OR=1.395 in the combined analysis of WTCCC, STEP-UCL and ED-DUB-STEP2 datasets. Genotyped P value=0.0014 in the WTCCC. Genotyped P value=0.0008 in the STEP-UCL. Genotyped P value=0.0002 in the ED-DUB-STEP2 dataset.
|
|
Positive
|
| rs2172835 |
C15orf53
|
|
T |
Genotyped P value=7.5E-07, OR=0.853 in the combined analysis of WTCCC, STEP-UCL and ED-DUB-STEP2 datasets. Genotyped P value=0.0314 in the WTCCC. Genotyped P value=0.0004 in the STEP-UCL. Genotyped P value=0.0011 in the ED-DUB-STEP2 dataset.
|
|
Trend
|
| rs1006737 |
CACNA1C
|
|
A |
Genotyped P value=7E-08, OR=1.181 in the combined analysis of WTCCC, STEP-UCL and ED-DUB-STEP2 datasets. Genotyped P value=0.0015 in the WTCCC. Genotyped P value=0.0003 in the STEP-UCL. Genotyped P value=0.0108 in the ED-DUB-STEP2 dataset.
|
|
Positive
|
| rs1024582 |
CACNA1C
CACNA1C-IT3
|
|
A |
Imputed P value=1.7E-08, OR=1.18 in the combined analysis of WTCCC, STEP-UCL and ED-DUB-STEP2 datasets. Imputed P value=0.0019 in the WTCCC. Imputed P value=0.0012 in the STEP-UCL. Imputed P value=0.0056 in the ED-DUB-STEP2 dataset.
|
|
Positive
|
| rs10994336 |
ANK3
|
|
T |
Imputed P value=9.1E-09, OR=1.45 in the combined analysis of WTCCC, STEP-UCL and ED-DUB-STEP2 datasets. Imputed P value=0.0006 in the WTCCC. Imputed P value=0.0004 in the STEP-UCL. Imputed P value=0.0002 in the ED-DUB-STEP2 dataset.
|
identified a region of strong association (rs10994336) in AN......
identified a region of strong association (rs10994336) in ANK3 (ankyrin G)
More...
|
Positive
|
| rs12899449 |
C15orf53
|
|
G |
Imputed P value=3.5E-08, OR=0.836 in the combined analysis of WTCCC, STEP-UCL and ED-DUB-STEP2 datasets. Imputed P value=0.014 in the WTCCC. Imputed P value=0.0005 in the STEP-UCL. Imputed P value=0.0013 in the ED-DUB-STEP2 dataset.
|
|
Positive
|
