BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Gawlik, M., 2006 PMID: 17081296
Citation	Gawlik, M., K. Moller-Ehrlich, et al. (2006). "Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits." BMC Psychiatry 6: 52.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	248 cases and 188 controls
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity	Caucasian
Population	German
Gender	154 male patients, 105 male controls
Age Group	adults : mean age=48.1 years of cases, mean age=30.2 years of controls

Detail Info

Sample Diagnosis	ICD10
Sample Status	The probands were recruited from 1996 to 2005 at the Department of Psychiatry and Psychotherapy at of the University of Wurzburg. The sample encompassed 248 cases (154 males) with recurrent depression and bipolar disorder. Patients also fulfilled the more restricted criteria of monopolar depression (n=57), and manic depression (n=191) in differentiated psychopathology.
Technique	genotyping
Statistical Method	Fisher's exact test and Armitage's trend test were used to compare allelic and genotypic distributions between cases and controls. Haplotype frequencies and global association were calculated with the program FAMHAP. For quantitative traits, they performed the Kruskal-Wallis test and analysis of variance (ANOVA) for single marker analysis and for haplotypes by using haplotype trend regression (HTR). Overall p-values were corrected for multiple testing, the statistics on allele and genotype distribution were uncorrected.
Result Summary	Allele and genotype frequencies of rs4713916, rs1360780 and rs3800373 were not significantly different between cases and controls. Two three-locus haplotypes, G-C-T and A-T-G, accounted for 86.2% in controls. Odds ratios were not increased between cases and controls, except the rare haplotype G-C-G (OR 6.81), representing 2.1% of cases and 0.3% of controls. The frequency of rs4713916AG in patients deviated from expected Hardy-Weinberg equilibrium, the genotype AA at rs4713916 in monopolar depression (P = 0.011), and the two-locus haplotype rs1360780T-rs3800373T in the total sample (overall P = 0.045) were nominally associated with longer continuance of disease. Their data do not support a significant genetic contribution of FKBP5 polymorphisms and haplotypes to affective psychosis, and the findings are inconclusive regarding their contribution to disease-related traits.

SNPs reported by this study for BD (count: 3)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs4713916	FKBP5	A/G		allelic P-value = 0.38, genotypic P-value = 0.12	Allele and genotype frequencies of rs4713916 were not signif...... Allele and genotype frequencies of rs4713916 were not significantly different between cases and controls. More...	Negative
rs3800373	FKBP5	T/G		allelic P-value = 0.23, genotypic P-value = 0.87	Allele and genotype frequencies of rs3800373 were not signif...... Allele and genotype frequencies of rs3800373 were not significantly different between cases and controls. More...	Negative
rs1360780	FKBP5	C/T		allelic P-value = 0.66, genotypic P-value = 0.86	Allele and genotype frequencies of rs1360780 were not signif...... Allele and genotype frequencies of rs1360780 were not significantly different between cases and controls. More...	Negative

Haplotypes reported by this study for BD (count: 8)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs4713916 - rs1360780 - rs3800373	A-C-T	FKBP5	OR=1.1		Negative
rs4713916 - rs1360780 - rs3800373	A-T-G	FKBP5	OR=1.18	In the studied population we found two haplotypes, G-C-T and...... In the studied population we found two haplotypes, G-C-T and A-T-G, with a cumulated frequency of 86.2% in controls. More...	Negative
rs4713916 - rs1360780 - rs3800373	G-C-T	FKBP5	OR=0.86	In the studied population we found two haplotypes, G-C-T and...... In the studied population we found two haplotypes, G-C-T and A-T-G, with a cumulated frequency of 86.2% in controls. More...	Negative
rs4713916 - rs1360780 - rs3800373	G-C-G	FKBP5	OR=6.81	Odds ratios were not increased between cases and controls, e...... Odds ratios were not increased between cases and controls, except the rare haplotype G-C-G (OR 6.81) representing 2.1% of cases, and 0.3% of controls. More...	Negative
rs4713916 - rs1360780 - rs3800373	A-C-G	FKBP5	OR=0.51		Negative
rs4713916 - rs1360780 - rs3800373	G-T-T	FKBP5	OR=0.82		Negative
rs4713916 - rs1360780 - rs3800373	A-T-T	FKBP5	OR=0.88		Negative
rs4713916 - rs1360780 - rs3800373	G-T-G	FKBP5	OR=0.8		Negative

Genes reported by this study for BD (count: 1)