Study Report

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Basic Info

Reference	Liu, C., 2007 PMID: 17957234
Citation	Liu, C., J. Shi, et al. (2007). "No association of trace amine receptor genes with bipolar disorder." Mol Psychiatry 12(11): 979-981.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Mutation study and candidate-gene association study
Sample Size	1310 samples consisted of 989 samples from the NIMH, 83 samples from the Clinical Neurogenetics (CNG) series, and 238 samples from the Chicago-Hopkins-Intramural Project (CHIP) series
SNP/Region/Marker Size	30 SNPs
Predominant Ethnicity	Caucasian
Population	NIMH, CNG and CHIP collections
Gender	not mentioned
Age Group	not mentioned

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	All affected children met DSM-IV criteria for bipolar or schizoaffective bipolar type based on the Diagnostic Instrument for Genetic Studies, medical records and information from family informants. They used the affection status model that includes BPI, BPII and schizoaffective bipolar type in their association analyses.
Technique	genotyping and resequencing
Statistical Method	The statistical power analysis performed using PBAT; TDT tests using ASPEX 2.5/sib_tdt; Haplotype blocks were identified by Haploview using the solid spine of LD and then analyzed for association by PDTPHASE.
Result Summary	The present study did not support strong association of either common or rare variants in the TAAR6 gene with BD susceptibility. SNPs rs8192624 and rs8192625 in TAAR6 and a haplotype in TAAR4 gene region remain interesting for possible minor contribution to disease susceptibility. Other candidate genes in this region should be further investigated.

SNPs reported by this study for BD (count: 45)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs12527371	TAAR9	G/A	TDT P-value = 0.59 in CNG+NIMH waves I+2		Negative
rs12189813	TAAR3 TAAR4P	C/G	TDT P-value = 0.45 in CNG+NIMH waves I+2, TDT P-value = 0.64 in NIMH waves 3+4 + CHIP, TDT P-value = 0.43 in Entire sample		Negative
rs9402439	TAAR1	C/G	TDT P-value = 0.3 in CNG+NIMH waves I+2		Negative
rs9389020	TAAR1	C/T	TDT P-value = 0.11 in CNG+NIMH waves I+2		Negative
rs9389011	TAAR2 TAAR3	C/T	TDT P-value = 0.35 in CNG+NIMH waves I+2, TDT P-value = 0.5 in NIMH waves 3+4 + CHIP, TDT P-value = 0.94 in Entire sample		Negative
rs9389008	TAAR5 TAAR4P	A/C	TDT P-value = 0.0069 in CNG+NIMH waves I+2, TDT P-value = 0.66 in NIMH waves 3+4 + CHIP, TDT P-value = 0.1 in Entire sample	TDT test detected this SNP is nominally associated with BD TDT test detected this SNP is nominally associated with BD	Positive
rs9373026	TAAR6	C>G		novel variant novel variant	Trend
rs9321360		C/G	TDT P-value = 0.023 in CNG+NIMH waves I+2, TDT P-value = 0.1 in NIMH waves 3+4 + CHIP, TDT P-value = 1 in Entire sample	TDT test detected this SNP is nominally associated with BD TDT test detected this SNP is nominally associated with BD	Positive
rs9321354	TAAR5	C/A	TDT P-value = 0.84 in CNG+NIMH waves I+2		Negative
rs8192625	TAAR6	A/G	TDT P-value = 0.16 in CNG+NIMH waves I+2, TDT P-value = 0.099 in NIMH waves 3+4 + CHIP, TDT P-value = 0.018 in Entire sample	it showed P not greater than 0.05 only in combined data anal...... it showed P not greater than 0.05 only in combined data analysis; we observed nominally significant association between minor allele (A) and BD More...	Positive
rs8192624	TAAR6	A/G	TDT P-value = 0.11 in CNG+NIMH waves I+2, TDT P-value = 0.022 in NIMH waves 3+4 + CHIP, TDT P-value = 0.0048 in Entire sample	SNP rs8192624 showed nominally significant association in th...... SNP rs8192624 showed nominally significant association in the second set of samples, as well as in the combined samples; we observed nominally significant association between minor allele (A) and BD More...	Positive
rs7772821	TAAR6 TAAR8	G/T	TDT P-value = 0.81 in CNG+NIMH waves I+2		Negative
rs7765655		G/A	TDT P-value = 0.56 in CNG+NIMH waves I+2		Negative
rs6903874	TAAR6	A/G	TDT P-value = 0.33 in CNG+NIMH waves I+2, TDT P-value = 0.27 in NIMH waves 3+4 + CHIP, TDT P-value = 0.15 in Entire sample		Negative
rs6907909	TAAR6	A/G	TDT P-value = 0.44 in CNG+NIMH waves I+2		Negative
rs6937506	TAAR6	G/A	TDT P-value = 0.42 in CNG+NIMH waves I+2, TDT P-value = 0.34 in NIMH waves 3+4 + CHIP, TDT P-value = 0.22 in Entire sample		Negative
rs7744878		A/G	TDT P-value = 0.4 in CNG+NIMH waves 1+2		Negative
rs4330555		A/G	TDT P-value = 1 in CNG+NIMH waves I+2		Negative
rs4473885	TAAR6	G/A	TDT P-value = 0.33 in CNG+NIMH waves I+2		Negative
rs4628126	TAAR4P	C/G	TDT P-value = 0.027 in CNG+NIMH waves I+2, TDT P-value = 0.5 in NIMH waves 3+4 + CHIP, TDT P-value = 0.05 in Entire sample	TDT test detected this SNP is nominally associated with BD a...... TDT test detected this SNP is nominally associated with BD and it showed P not greater than 0.05 only in combined data analysis More...	Positive
rs6902492		C/G	TDT P-value = 0.38 in CNG+NIMH waves I+2		Negative
rs41298397	TAAR6	T>C		novel variant novel variant	Trend
rs41298399	TAAR6	A>G		novel variant novel variant	Trend
rs4305745	TAAR6	G/A	TDT P-value = 0.51 in CNG+NIMH waves I+2, TDT P-value = 0.27 in NIMH waves 3+4 + CHIP, TDT P-value = 0.25 in Entire sample		Negative
rs4320395	TAAR4P	A/G	TDT P-value = 0.35 in CNG+NIMH waves I+2, TDT P-value = 1 in NIMH waves 3+4 + CHIP, TDT P-value = 0.52 in Entire sample		Negative
rs41298389	TAAR6	C>T		novel variant novel variant	Trend
rs41298391	TAAR6	T>C		novel variant novel variant	Trend
rs41298393	TAAR6	C>T		novel variant novel variant	Trend
rs41298395	TAAR6	A>G		novel variant novel variant	Trend
rs41298383	TAAR6	A>T		novel variant novel variant	Trend
rs41298381	TAAR6	A>G		novel variant novel variant	Trend
rs41298387	TAAR6	A>T		novel variant novel variant	Trend
rs41298385	TAAR6	G>A		novel variant novel variant	Trend
rs41297597	TAAR6	A>C		novel variant novel variant	Trend
rs41297595	TAAR6	T>C		novel variant novel variant	Trend
rs41297601	TAAR6	T>C		novel variant novel variant	Trend
rs41297599	TAAR6	A>G		novel variant novel variant	Trend
rs2842899	TAAR9	A/T	TDT P-value = 0.8 in CNG+NIMH waves I+2		Negative
rs2745438		A/G	TDT P-value = 0.3 in CNG+NIMH waves I+2		Negative
rs4129284		T/C	TDT P-value = 0.21 in CNG+NIMH waves 1+2		Negative
rs3813355	TAAR5 TAAR4P	A/G	TDT P-value = 0.58 in CNG+NIMH waves I+2		Negative
rs1933988	TAAR8	A/C	TDT P-value = 0.67 in CNG+NIMH waves I+2		Negative
rs1569651		C/A	TDT P-value = 0.041 in CNG+NIMH waves I+2, TDT P-value = 0.077 in NIMH waves 3+4 + CHIP, TDT P-value = 0.82 in Entire sample	TDT test detected this SNP is nominally associated with BD TDT test detected this SNP is nominally associated with BD	Positive
rs2153174	TAAR9	G/T	TDT P-value = 0.78 in CNG+NIMH waves I+2		Negative
rs2066076		A/C	TDT P-value = 1 in CNG+NIMH waves I+2		Negative

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs9389008 - rs4628126 - rs4320395 - rs12189813		TAAR4P	P-value = 0.0063, P-value = 0.13 in the second set sample (Waves 3-4 & CHIP); P-value = 0.015 in combined data	One distal haplotype in the TAAR4 gene showed nominal associ...... One distal haplotype in the TAAR4 gene showed nominal association with BD More...	Positive

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
TAAR6	The present study did not support strong association of either common or rare variants in the TAAR6 ...... The present study did not support strong association of either common or rare variants in the TAAR6 gene with BD susceptibility, but SNPs rs8192624 and rs8192625 remain interesting for possible minor contribution to disease susceptibility. More...	Positive
TAAR4P	A haplotype in TAAR4 gene region remain interesting for possible minor contribution to disease susce...... A haplotype in TAAR4 gene region remain interesting for possible minor contribution to disease susceptibility. More...	Positive