BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Liang, S. G.,2002 PMID: 12454528
Citation	Liang, S. G., A. D. Sadovnick, et al. (2002). "A linkage disequilibrium study of bipolar disorder and microsatellite markers on 22q13." Psychiatr Genet 12(4): 231-235.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Candidate-region linkage study
Sample Size	142 parent-proband triads
SNP/Region/Marker Size	10 microsatellite markers spanning an interval of 2.3 MB on 22q13
Predominant Ethnicity
Population	American and NIMH collections

Detail Info

Sample Diagnosis	DSM
Sample Status	Families for this study came from two different clinical collections.Thi rty-six multiplex families were ascertained through a proband with bipolar I or bipolar II collected at one of three sites (San Diego, Vancouver, and Cincinnati) as part of a collaborative linkage study of bipolar disorder.Nuclear families were selected from this sample for linkage disequilibrium studies using the TDT.Thirty -one of these families included a proband and both parents, two included an affected sibpair and both parents, and three families included three affected sibs and both parents. DNA samples for an additional 106 nuclear families were obtained for subjects selected from multiplex families collected as part of the NIMH Genetics Initiative for Bipolar Disorder.Thirty - eight of these families included a proband and both parents, while 68 included an affected sibpair and both parents.
Technique	genotyping
Statistical Method	Transmission Disequilibrium Test (TDT)
Result Summary	Haplotypes were determined and marker-to-marker linkage disequilibrium across the region was examined. D22S281 and D22S685 yielded suggestive evidence of linkage disequilibrium to bipolar disorder (empirical values of 0.023 and 0.036, respectively), but a marker-to-marker analysis indicates that a higher density screen is needed to adequately analyze this region.

Regions reported by this study for BD (count: 1)