Study Report
Basic Info
| Reference |
Schosser, A.,2004 PMID: 15003442
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| Citation |
Schosser, A., K. Fuchs, et al. (2004). "Possible linkage of schizophrenia and bipolar affective disorder to chromosome 3q29; a follow-up." J Psychiatr Res 38(3): 357-364.
|
| Disease Type |
Bipolar Disorder & Schizophrenia |
| Study Design |
pedigree |
| Study Type |
Candidate-region linkage study |
| Sample Size |
five pedigrees with schizophrenic index patients and three pedigrees with index bipolar disorder patients N=86; 50 of them were available for genotyping |
| SNP/Region/Marker Size |
8 SNPs spanning a 4.14 cM region on chromosome 3q29 |
| Predominant Ethnicity |
Caucasian |
| Population |
Austrian |
| Gender |
Of the genotyped affected, 70% were women. |
| Age Group |
Adults
:
Mean age was 41.59 (S.D. 18.86) years of age at interview. The mean age at onset was 26.33 (S.D. 10.87) years.
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Detail Info
| Sample Diagnosis |
DSM |
| Sample Status |
Within this study, DNA of the same family-sample as in the recently published genome scan (Bailer et al., 2002) was genotyped. Five pedigrees with schizophrenic indexpatie nts and three pedigrees with indexbipolar disorder patients (N=86; 50 of them were available for genotyping) were investigated in Vienna. The families were ethnically homogenous of Austrian origin. The disease model (affected individuals) of the current analysis included schizophrenia, schizophrenia spectrum disorders (i.e., schizophreniform disorder, delusional disorder, atypical psychosis, schizoaffective disorder), bipolar affective disorder, and recurrent unipolar depression. Age at onset was defined as age at first hospitalization for the disorder. All 27 patients had been hospitalized during the course of their illness. |
| Technique |
genotyping |
| Statistical Method |
Linkage was performed using the GENEHUNTER program version 2.1r3 to compute both the usual parametric logarithm of the likelihood of linkage (LOD) scores (a dominant model was used), as well as the nonparametric multipoint linkage (NPL) score Zall (for details, see Kruglyak et al., 1996). |
| Result Summary |
Within newly genotyped markers the highest NPL score Z(all) observed was 1.93296 with the telomeric SNP (single nucleotide polymorphism) rs1835669, corresponding to P=0.032166. Statistical analysis including D3S1265, located in between the newly genotyped markers, resulted in a peak NPL score Z(all)=4.00179 with marker D3S1265, that is P=0.000128. Doing subset analyses of the bipolar disorder and schizophrenia families separately with new markers and D3S1265, linkage signals arose substantially from bipolar disorder families, with contribution from schizophrenia families, too. The results of our follow-up study support our previous linkage finding of schizophrenia and bipolar affective disorder to chromosome 3q29. |
Genetic factors reported by this study for BD
Regions reported by this study for BD (count: 1)
| Region |
Statistical Values |
Author Comments |
Result Category |
| 3q29 |
Linkage analysis: For marker D3S1265, LOD = 1.61193, NPL = 3.56441, P-value = 0.001038
|
Suggestive linkage was found in this region.
Suggestive linkage was found in this region.
|
Trend
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Genetic factors reported by this study for SZ and/or MDD
Regions reported by this study for SZ/MDD
| Disease |
Region Name |
Statistical Values |
Description |
Result Category |
| SZ |
3q29 |
Linkage analysis:D3S1265, LOD=0.356281, NPL=2.30093, P-value = 0.009155 |
Suggestive linkage was found in this region. |
Trend |
