Study Report
Basic Info
| Reference |
Schosser, A.,2007 PMID: 17344034
|
| Citation |
Schosser, A., K. Fuchs, et al. (2007). "Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29." Eur Neuropsychopharmacol 17(6-7): 501-505.
|
| Disease Type |
Bipolar Disorder & Schizophrenia |
| Study Design |
pedigree |
| Study Type |
Candidate-region linkage study |
| Sample Size |
Five pedigrees with schizophrenic index patients and three pedigrees with index bipolar disorder patients (N=86; 50 of them were available for genotyping) |
| SNP/Region/Marker Size |
11 SNP markers in one chromosomal region |
| Predominant Ethnicity |
|
| Population |
Australian |
Detail Info
| Sample Diagnosis |
DSM |
| Technique |
genotyping |
| Statistical Method |
Linkage was performed using the GENEHUNTER program version 2.1r3 to compute both the usual parametric logarithm of the likelihood of linkage (LOD) scores (a dominant model was used as described; Schosser et al., 2004), as well as the nonparametric multipoint linkage (NPL) score Zall (for details, see Kruglyak et al.,1996). |
| Result Summary |
A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs). |
Genetic factors reported by this study for BD
Regions reported by this study for BD (count: 1)
| Region |
Statistical Values |
Author Comments |
Result Category |
| 3q29 |
Linkage analyses: For marker rs225, LOD = 1.483, NPL = 4.0465, P-value = 0.000549 for BD.
|
Significant linkage was found in this region.
Significant linkage was found in this region.
|
Positive
|
Genetic factors reported by this study for SZ and/or MDD
Regions reported by this study for SZ/MDD
| Disease |
Region Name |
Statistical Values |
Description |
Result Category |
| SZ |
3q29 |
Linkage analyses:rs538885, LOD=0.3195, NPL=1.7889, P-value = 0.042786 for SZ. |
No positive linkage was found in this region. |
Negative |
