BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Zhao, Q.,2011 PMID: 20537720
Citation	Zhao, Q., R. Che, et al. (2011). "Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population." Psychiatry Res 185(1-2): 290-292.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	480 patients with bipolar disorder and 480 normal controls
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	Male/female:271/209 in BD patients and 280/200 in controls
Age Group	Adults : Mean age(SD)(year):37.9(12.7)[26.7(10.6) at onset] in BD patients and 36.4(7.2) in controls

Detail Info

SNPs reported by this study for BD (count: 3)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs7301328	GRIN2B	C/G		X² test: allele, OR(95%CI)=1.13(0.94-1.35), X²=1.677, P-value = 0.195, genotype, X²=2.096, P-value = 0.351	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1805502	GRIN2B	A/G		X² test: allele, OR(95%CI)=1.11(0.89-1.39), X²=0.818, P-value = 0.366, genotype, X²=0.884, P-value = 0.643	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1805247	GRIN2B	A/G		X² test: allele, OR(95%CI)=1.32(1.06-1.65), X²=5.973, P-value(permutated P-value)=0.015(0.018), genotype, X²=6.184, P-value = 0.046	Significant association was found in BPD. Significant association was found in BPD.	Positive

Haplotypes reported by this study for BD (count: 3)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs1805502 - rs1805247	A-G	GRIN2B	Haplotypic association:X<sup>2</sup>=38.25, P-value = 6.22E-10	Significant association was found in BPD. Significant association was found in BPD.	Positive
rs1805502 - rs1805247	G-G	GRIN2B	Haplotypic association:X<sup>2</sup>=0.121, P-value = 0.728	No significant association was found . No significant association was found .	Negative
rs1805502 - rs1805247	A-A	GRIN2B	Haplotypic association:X<sup>2</sup>=6.286, P-value = 0.012	Significant association was found in BPD. Significant association was found in BPD.	Positive

Genes reported by this study for BD (count: 1)