BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Xiao, Y.,2011 PMID: 21222298
Citation	Xiao, Y., J. Zhang, et al. (2011). "Limited association between Disrupted in Schizophrenia 1 (DISC1) gene and bipolar disorder in the Chinese population." Psychiatr Genet 21(1): 42-46.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	506 bipolar patients and 507 controls
SNP/Region/Marker Size	12 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	Male/female:284/222 in BD patients and 287/220 in controls
Age Group	Adults : Mean age(SD)(year):37.8(11.4)[26.7(10.6) at onset] in BD patients and 36.4(8.7) in controls

Detail Info

SNPs reported by this study for BD (count: 11)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs1572899	DISC1	C/G	C	Allelic permutated P-value = 1, genotypic permutated P-value = 0.7	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1538977	DISC1 TSNAX	A/G	A	Allelic permutated P-value = 0.999, genotypic permutated P-value = 0.702	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1954175	DISC1 TSNAX	C/T	C	Allelic permutated P-value = 1, genotypic permutated P-value = 0.674	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs16841582	DISC1	C/G	C	Allelic permutated P-value = 0.35, genotypic permutated P-value = 0.047	Significant association was found in genotype. Significant association was found in genotype.	Positive
rs1417866	DISC1	A/G	A	Allelic permutated P-value = 0.987, genotypic permutated P-value = 0.509	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs821653	DISC1	A/G	A	Allelic permutated P-value = 0.999, genotypic permutated P-value = 0.737	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs821597	DISC1 TSNAX	A/G	A	Allelic permutated P-value = 0.998, genotypic permutated P-value = 0.266	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2738864	DISC1	C/T	C	Allelic permutated P-value = 0.114, genotypic permutated P-value = 0.061	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2038636	DISC1 TSNAX	A/G	A	Allelic permutated P-value = 0.884, genotypic permutated P-value = 0.308	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs734551	DISC1 TSNAX	A/G	A	Allelic permutated P-value = 0.882, genotypic permutated P-value = 0.431	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs3524	DISC1	A/G	A	Allelic permutated P-value = 0.45, genotypic permutated P-value = 0.196	No significant association was observed in BD. No significant association was observed in BD.	Negative

Haplotypes reported by this study for BD (count: 3)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs1572899 - rs1954175	A-C	DISC1	Haplotype analysis:individual P-value = 0.987	No significant association was found . No significant association was found .	Negative
rs821597 - rs821653	A-A	DISC1	Haplotype analysis:individual P-value = 0.9924	No significant association was found . No significant association was found .	Negative
rs2738864 - rs16841582	C-C	DISC1	Haplotype analysis:individual P-value = 0.0191	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive

Genes reported by this study for BD (count: 1)