Study Report
Basic Info
| Reference |
Doyle, G. A.,2011 PMID: 20978456
|
| Citation |
Doyle, G. A., J. P. Dahl, et al. (2011). "Association study of polymorphisms in the autosomal mitochondrial complex I subunit gene, NADH dehydrogenase (ubiquinone) flavoprotein 2, and bipolar disorder." Psychiatr Genet 21(1): 51-52.
|
| Disease Type |
Bipolar I Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
741 control and 569 BPDI individuals |
| SNP/Region/Marker Size |
3 SNPs |
| Predominant Ethnicity |
|
| Population |
NIMH collections |
Detail Info
| Statistical Method |
chi-square test |
| Result Summary |
All SNPs were in Hardy-Weinberg equilibrium.There were no statistically significant associations between genotypes and BPDI at rs2377961.The 'A' allele at rs1156044 and 'C' allele at rs906807 were nominally associated with BPDI.Statistical significances of the allelic associations in the present study were not upheld after Bonferroni correction (alpha=0.0167 for 3 tests).In haplotype (rs1156044-rs906807) analysis.the 'AC' haplotype showed statistical significance after Bonferroni correction (alpha=0.0125 for 4 haplotype comparisons).However, after 10,000 permutations of our data, no associations remained statistically significant (lowest permutation adjusted p-value=0.064 for the 'AC' haplotype). Thus, we cautiously conclude that NDUFV2 may be associated with BPDI in this Caucasian population. |
SNPs reported by this study for BD (count: 3)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs906807 |
NDUFV2
|
G/A |
A |
chi suqare test: genotype, X2=4.711, P-value = 0.095; allele A, X2=5.362, P-value = 0.021
|
Significant association was found in allele association.
Significant association was found in allele association.
|
Positive
|
| rs1156044 |
NDUFV2
|
C/T |
C |
chi suqare test: genotype, X2=5.798, P-value = 0.055; allele C, X2=4.173, P-value = 0.041
|
Significant association was found in allele association.
Significant association was found in allele association.
|
Positive
|
| rs2377961 |
NDUFV2
|
C/T |
|
chi suqare test: genotype, X2=3.873, P-value = 0.144; allele, X2=0.572, P-value = 0.449
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Haplotypes reported by this study for BD (count: 3)
| Markers |
Haplotype |
Related Gene(s)/Region(s) |
Statistical Values |
Author Comments |
Result Category |
| rs1156044 - rs906807 |
A-T |
NDUFV2
|
Haplotype analysis:X<sup>2</sup>=1.259, P-value = 0.262
|
No significant association was observed in BPDI.
No significant association was observed in BPDI.
|
Negative
|
| rs1156044 - rs906807 |
G-T |
NDUFV2
|
Haplotype analysis:X<sup>2</sup>=2.765, P-value = 0.096
|
No significant association was observed in BPDI.
No significant association was observed in BPDI.
|
Negative
|
| rs1156044 - rs906807 |
A-C |
NDUFV2
|
Haplotype analysis:X<sup>2</sup>=7.033, P-value = 0.008 after Bonferroni correction; lowest permutation adjusted P-value = 0.064
|
Significant association was found in global P-value.
Significant association was found in global P-value.
|
Positive
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| NDUFV2 |
We cautiously conclude that NDUFV2 may be associated with BPDI in this Caucasian population.
We cautiously conclude that NDUFV2 may be associated with BPDI in this Caucasian population.
|
Positive
|
