Study Report

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Basic Info

Reference	Athanasiu, L.,2011 PMID: 20554328
Citation	Athanasiu, L., M. Mattingsdal, et al. (2011). "Intron 12 in NTRK3 is associated with bipolar disorder." Psychiatry Res 185(3): 358-362.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	194 patients diagnosed with bipolar disorder and 336 healthy controls
SNP/Region/Marker Size	149 SNPs
Predominant Ethnicity	Caucasian
Population	Norwegian

Detail Info

Sample Diagnosis	DSM
Sample Status	Patients. The subjects participated in a large ongoing study on BD Thematically Organized Psychosis (Top) Study and were recruited from out-patient and in-patient psychiatric units at four University Hospitals in Oslo and Trondheim, Norway, from May, 2003 through July, 2007. The health care system is catchment area based, free of charge, and no other psychiatric health care provider exists. The patients were invited to participate in the study by the clinician responsible for their treatment.The majority (90%) of the patients were ethnical Norwegian, i.e. the patient and both parents were born in Norway, while in a minor fraction of the cases (10%) one parent was born outside Norway in another North-western European country.Healthy controls The healthy controls subjects were randomly selected from statistical records of persons from the same catchments area as the patient groups. Only subjects born in Norway were contacted by letter and invited to participate. All controls were of Caucasian origin; around 85% had two Norwegian parents, the rest one parent from other European origin. Moreover, all participants had to have Norwegian as their first language or have received their compulsory schooling in Norway. The control subjects were screened by interview and with the Primary Care Evaluation of Mental Disorders (PRIME-MD). None of the control subjects had a history of moderate/severe head injury, neurological disorder, mental retardation or an age outside the age range of 18-60 years. Healthy subjects were excluded if they or any of their close relatives had a lifetime history of a severe psychiatric disorder (SCZ, BD and major depression), a history of medical problems thought to interfere with brain function (hypothyroidism, uncontrolled hypertension and diabetes), or significant illicit drug use.
Technique	genotyping
Statistical Method	The TOP data were analyzed for NTRK3-BD association using the basic case/control allelic association test and the genotype-based Cochran-Armitage trend test, implemented in PLINK. In addition, logistic regression was used to perform haplotype-based association analyses in intron 12, using the sliding window approach with window-sizes between 2 and 10, also implemented in PLINK.
Result Summary	In total 149 markers were investigated for SNP-disease association. Polymorphisms in over 20 markers were nominally associated with bipolar disorder, covering intron 5 to intron 12. Interestingly, our markers appeared to be located close or within the linkage regions reported in schizophrenia, early-onset major depressive disorder and eating disorder, supporting the hypothesis that some genes influence risk beyond traditional diagnostic boundaries.

SNPs reported by this study for BD (count: 144)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs11073768	NTRK3	A/G	Allelic association: OR=0.757, P-value = 1.55E-01, P-value(trend)=1.55E-01	No significant association was observed. No significant association was observed.	Negative
rs11073759	NTRK3	A/G	Allelic association: OR=1.258, P-value = 2.21E-01, P-value(trend)=2.34E-01	No significant association was observed. No significant association was observed.	Negative
rs11630338	NTRK3	C/T	Allelic association: OR=1.696, P-value = 2.97E-04, P-value(trend)=1.61E-04	Significant associations were found . Significant associations were found .	Positive
rs11073771	NTRK3	A/T	Allelic association: OR=1.207, P-value = 1.96E-01, P-value(trend)=1.95E-01	No significant association was observed. No significant association was observed.	Negative
rs11073746	NTRK3	G/C	Allelic association: OR=0.8908, P-value = 3.77E-01, P-value(trend)=3.60E-01	No significant association was observed. No significant association was observed.	Negative
rs11073737	NTRK3	G/A	Allelic association: OR=0.8965, P-value = 4.14E-01, P-value(trend)=4.14E-01	No significant association was observed. No significant association was observed.	Negative
rs11073758	NTRK3	G/A	Allelic association: OR=1.314, P-value = 3.40E-02, P-value(trend)=3.42E-02	Significant associations were found . Significant associations were found .	Positive
rs11073752	NTRK3	C/T	Allelic association: OR=0.9736, P-value = 8.49E-01, P-value(trend)=8.44E-01	No significant association was observed. No significant association was observed.	Negative
rs1073723	NTRK3	C/T	Allelic association: OR=1.096, P-value = 4.76E-01, P-value(trend)=4.59E-01	No significant association was observed. No significant association was observed.	Negative
rs10520676	NTRK3	A/G	Allelic association: OR=0.7141, P-value = 3.82E-02, P-value(trend)=3.53E-02	Significant associations were found . Significant associations were found .	Positive
rs1105442	NTRK3	T/C	Allelic association: OR=1.687, P-value = 3.87E-04, P-value(trend)=2.36E-04	Significant associations were found . Significant associations were found .	Positive
rs1075891	NTRK3	T/C	Allelic association: OR=0.8242, P-value = 3.15E-01, P-value(trend)=2.93E-01	No significant association was observed. No significant association was observed.	Negative
rs1017757	NTRK3	G/A	Allelic association: OR=1.207, P-value = 2.84E-01, P-value(trend)=2.92E-01	No significant association was observed. No significant association was observed.	Negative
rs10163123	NTRK3	G/C	Allelic association: OR=0.6964, P-value = 1.14E-02, P-value(trend)=1.20E-02	Significant associations were found . Significant associations were found .	Positive
rs10520673	NTRK3	T/C	Allelic association: OR=0.9312, P-value = 5.89E-01, P-value(trend)=5.85E-01	No significant association was observed. No significant association was observed.	Negative
rs10520671	NTRK3	G/C	Allelic association: OR=1.293, P-value = 1.69E-01, P-value(trend)=1.80E-01	No significant association was observed. No significant association was observed.	Negative
rs12593792	NTRK3	T/C	Allelic association: OR=0.9481, P-value = 7.42E-01, P-value(trend)=7.47E-01	No significant association was observed. No significant association was observed.	Negative
rs12595693	NTRK3	A/G	Allelic association: OR=0.8232, P-value = 2.80E-01, P-value(trend)=2.84E-01	No significant association was observed. No significant association was observed.	Negative
rs12591487	NTRK3	C/T	Allelic association: OR=0.765, P-value = 1.04E-01, P-value(trend)=1.07E-01	Significant associations were found . Significant associations were found .	Positive
rs12591645	NTRK3	A/G	Allelic association: OR=1.137, P-value = 3.17E-01, P-value(trend)=3.13E-01	No significant association was observed. No significant association was observed.	Negative
rs12443330	NTRK3	G/C	Allelic association: OR=1.069, P-value = 6.35E-01, P-value(trend)=6.27E-01	No significant association was observed. No significant association was observed.	Negative
rs12591318	NTRK3	T/C	Allelic association: OR=0.8024, P-value = 2.74E-01, P-value(trend)=2.62E-01	No significant association was observed. No significant association was observed.	Negative
rs12441487	NTRK3	G/A	Allelic association: OR=1.382, P-value = 1.94E-02, P-value(trend)=1.97E-02	Significant associations were found . Significant associations were found .	Positive
rs12441513	NTRK3	A/G	Allelic association: OR=1.267, P-value = 2.28E-01, P-value(trend)=2.24E-01	No significant association was observed. No significant association was observed.	Negative
rs12148667	NTRK3	T/G	Allelic association: OR=0.8651, P-value = 2.70E-01, P-value(trend)=2.89E-01	No significant association was observed. No significant association was observed.	Negative
rs12324332	NTRK3	C/G	Allelic association: OR=1.292, P-value = 1.44E-01, P-value(trend)=1.50E-01	No significant association was observed. No significant association was observed.	Negative
rs11635754	NTRK3-AS1 NTRK3	G/T	Allelic association: OR=1.181, P-value = 2.45E-01, P-value(trend)=2.38E-01	No significant association was observed. No significant association was observed.	Negative
rs11638486	NTRK3	T/C	Allelic association: OR=0.9925, P-value = 9.60E-01, P-value(trend)=9.59E-01	No significant association was observed. No significant association was observed.	Negative
rs11632716	NTRK3	G/C	Allelic association: OR=1.014, P-value = 9.45E-01, P-value(trend)=9.45E-01	No significant association was observed. No significant association was observed.	Negative
rs11634388	NTRK3	G/C	Allelic association: OR=1.056, P-value = 7.10E-01, P-value(trend)=7.06E-01	No significant association was observed. No significant association was observed.	Negative
rs11631112	NTRK3	T/G	Allelic association: OR=1.63, P-value = 8.10E-04, P-value(trend)=4.62E-04	Significant associations were found . Significant associations were found .	Positive
rs11631508	NTRK3	G/A	Allelic association: OR=1.404, P-value = 1.45E-02, P-value(trend)=1.32E-02	Significant associations were found . Significant associations were found .	Positive
rs1465747	NTRK3	T/C	Allelic association: OR=1.22, P-value = 1.31E-01, P-value(trend)=1.17E-01	No significant association was observed. No significant association was observed.	Negative
rs1461214	NTRK3	G/C	Allelic association: OR=1.188, P-value = 2.86E-01, P-value(trend)=2.96E-01	No significant association was observed. No significant association was observed.	Negative
rs1435403	NTRK3	A/G	Allelic association: OR=0.9756, P-value = 8.76E-01, P-value(trend)=8.73E-01	No significant association was observed. No significant association was observed.	Negative
rs1435397	NTRK3	G/A	Allelic association: OR=1.52, P-value = 6.83E-03, P-value(trend)=8.12E-03	No significant association was observed. No significant association was observed.	Negative
rs1381112	NTRK3	G/A	Allelic association: OR=0.7769, P-value = 2.03E-01, P-value(trend)=2.06E-01	No significant association was observed. No significant association was observed.	Negative
rs1369427	NTRK3	C/T	Allelic association: OR=0.952, P-value = 8.06E-01, P-value(trend)=8.03E-01	No significant association was observed. No significant association was observed.	Negative
rs1369417	NTRK3	T/C	Allelic association: OR=0.9356, P-value = 6.39E-01, P-value(trend)=6.31E-01	No significant association was observed. No significant association was observed.	Negative
rs1369416	NTRK3	G/A	Allelic association: OR=1.076, P-value = 5.72E-01, P-value(trend)=5.76E-01	No significant association was observed. No significant association was observed.	Negative
rs1346164	NTRK3	C/G	Allelic association: OR=0.7506, P-value = 4.61E-02, P-value(trend)=4.96E-02	Significant associations were found . Significant associations were found .	Positive
rs13380271	NTRK3	T/C	Allelic association: OR=1.226, P-value = 1.20E-01, P-value(trend)=1.17E-01	No significant association was observed. No significant association was observed.	Negative
rs13329385	NTRK3	C/T	Allelic association: OR=0.8918, P-value = 4.44E-01, P-value(trend)=4.57E-01	Significant associations were found . Significant associations were found .	Positive
rs13313527	NTRK3	A/G	Allelic association: OR=1.129, P-value = 3.61E-01, P-value(trend)=3.61E-01	No significant association was observed. No significant association was observed.	Negative
rs12911150	NTRK3	G/T	Allelic association: OR=1.438, P-value = 1.49E-02, P-value(trend)=1.32E-02	Significant associations were found . Significant associations were found .	Positive
rs12907837	NTRK3	C/A	Allelic association: OR=0.9559, P-value = 8.49E-01, P-value(trend)=8.52E-01	No significant association was observed. No significant association was observed.	Negative
rs12903567	NTRK3	A/G	Allelic association: OR=1.029, P-value = 8.87E-01, P-value(trend)=8.87E-01	No significant association was observed. No significant association was observed.	Negative
rs12901745	NTRK3	T/C	Allelic association: OR=0.8479, P-value = 2.14E-01, P-value(trend)=2.29E-01	No significant association was observed. No significant association was observed.	Negative
rs7175493	NTRK3	C/T	Allelic association: OR=0.8852, P-value = 3.52E-01, P-value(trend)=3.72E-01	No significant association was observed. No significant association was observed.	Negative
rs717320	NTRK3	G/A	Allelic association: OR=0.9097, P-value = 4.77E-01, P-value(trend)=4.78E-01	No significant association was observed. No significant association was observed.	Negative
rs7178884	NTRK3	A/T	Allelic association: OR=1.089, P-value = 6.58E-01, P-value(trend)=6.62E-01	No significant association was observed. No significant association was observed.	Negative
rs7175941	NTRK3	C/T	Allelic association: OR=1.559, P-value = 9.75E-03, P-value(trend)=1.01E-02	Significant associations were found . Significant associations were found .	Positive
rs7169789	NTRK3	A/G	Allelic association: OR=0.7869, P-value = 2.49E-01, P-value(trend)=2.36E-01	No significant association was observed. No significant association was observed.	Negative
rs7168662	NTRK3	G/A	Allelic association: OR=1.012, P-value = 9.51E-01, P-value(trend)=9.52E-01	No significant association was observed. No significant association was observed.	Negative
rs7170215	NTRK3	T/A	Allelic association: OR=1.273, P-value = 6.07E-02, P-value(trend)=6.23E-02	No significant association was observed. No significant association was observed.	Negative
rs7170062	NTRK3	C/T	Allelic association: OR=1.215, P-value = 1.28E-01, P-value(trend)=1.29E-01	No significant association was observed. No significant association was observed.	Negative
rs8025158	NTRK3	A/G	Allelic association: OR=0.8591, P-value = 3.28E-01, P-value(trend)=3.37E-01	Significant associations were found . Significant associations were found .	Positive
rs8023765	NTRK3	A/G	Allelic association: OR=1.108, P-value = 5.71E-01, P-value(trend)=5.81E-01	No significant association was observed. No significant association was observed.	Negative
rs8033409	NTRK3	G/A	Allelic association: OR=0.9369, P-value = 7.80E-01, P-value(trend)=7.81E-01	No significant association was observed. No significant association was observed.	Negative
rs8026216	NTRK3	A/C	Allelic association: OR=0.8572, P-value = 4.21E-01, P-value(trend)=4.00E-01	No significant association was observed. No significant association was observed.	Negative
rs7182329	NTRK3	A/G	Allelic association: OR=1.221, P-value = 1.35E-01, P-value(trend)=1.37E-01	No significant association was observed. No significant association was observed.	Negative
rs7179067	NTRK3	A/G	Allelic association: OR=0.9886, P-value = 9.34E-01, P-value(trend)=9.35E-01	No significant association was observed. No significant association was observed.	Negative
rs744994	NTRK3 NTRK3-AS1	A/G	Allelic association: OR=1.044, P-value = 7.46E-01, P-value(trend)=7.37E-01	No significant association was observed. No significant association was observed.	Negative
rs744993	NTRK3 NTRK3-AS1	A/C	Allelic association: OR=0.9637, P-value = 8.34E-01, P-value(trend)=8.31E-01	No significant association was observed. No significant association was observed.	Negative
rs873897	NTRK3	A/T	Allelic association: OR=0.9513, P-value = 7.18E-01, P-value(trend)=7.23E-01	No significant association was observed. No significant association was observed.	Negative
rs894290	NTRK3	G/A	Allelic association: OR=0.9795, P-value = 8.98E-01, P-value(trend)=9.01E-01	No significant association was observed. No significant association was observed.	Negative
rs894291	NTRK3	A/G	Allelic association: OR=1.06, P-value = 7.25E-01, P-value(trend)=7.30E-01	No significant association was observed. No significant association was observed.	Negative
rs920067	NTRK3	C/G	Allelic association: OR=1.152, P-value = 2.81E-01, P-value(trend)=2.89E-01	No significant association was observed. No significant association was observed.	Negative
rs8035178	NTRK3	C/G	Allelic association: OR=1.048, P-value = 7.11E-01, P-value(trend)=7.18E-01	No significant association was observed. No significant association was observed.	Negative
rs8035265	NTRK3	T/G	Allelic association: OR=1.477, P-value = 3.20E-03, P-value(trend)=3.64E-03	Significant associations were found . Significant associations were found .	Positive
rs8036369	NTRK3	C/G	Allelic association: OR=0.8252, P-value = 1.42E-01, P-value(trend)=1.59E-01	No significant association was observed. No significant association was observed.	Negative
rs8039186	NTRK3	T/C	Allelic association: OR=1.239, P-value = 9.96E-02, P-value(trend)=9.50E-02	No significant association was observed. No significant association was observed.	Negative
rs991728	NTRK3	G/C	Allelic association: OR=1.696, P-value = 2.97E-04, P-value(trend)=1.61E-04	Significant associations were found . Significant associations were found .	Positive
rs9920842	NTRK3	T/C	Allelic association: OR=0.9341, P-value = 6.62E-01, P-value(trend)=6.59E-01	No significant association was observed. No significant association was observed.	Negative
rs994068	NTRK3	C/G	Allelic association: OR=1.688, P-value = 2.28E-04, P-value(trend)=8.95E-05	Significant associations were found . Significant associations were found .	Positive
rs998636	NTRK3-AS1 NTRK3	C/T	Allelic association: OR=1.167, P-value = 3.19E-01, P-value(trend)=3.23E-01	No significant association was observed. No significant association was observed.	Negative
rs958699	NTRK3	G/C	Allelic association: OR=1.095, P-value = 6.27E-01, P-value(trend)=6.23E-01	No significant association was observed. No significant association was observed.	Negative
rs958700	NTRK3	A/G	Allelic association: OR=1.065, P-value = 7.11E-01, P-value(trend)=7.10E-01	No significant association was observed. No significant association was observed.	Negative
rs9635402	NTRK3	C/T	Allelic association: OR=0.9317, P-value = 6.26E-01, P-value(trend)=6.16E-01	No significant association was observed. No significant association was observed.	Negative
rs9806762	NTRK3	G/A	Allelic association: OR=0.6798, P-value = 4.17E-03, P-value(trend)=5.11E-03	Significant associations were found . Significant associations were found .	Positive
rs1560976	NTRK3	G/A	Allelic association: OR=0.9363, P-value = 6.20E-01, P-value(trend)=6.20E-01	No significant association was observed. No significant association was observed.	Negative
rs1559822	NTRK3	A/G	Allelic association: OR=0.7945, P-value = 2.52E-01, P-value(trend)=2.40E-01	No significant association was observed. No significant association was observed.	Negative
rs16940895	NTRK3	A/C	Allelic association: OR=1.786, P-value = 3.03E-02, P-value(trend)=3.46E-02	No significant association was observed. No significant association was observed.	Negative
rs1560977	NTRK3	C/T	Allelic association: OR=0.9363, P-value = 6.20E-01, P-value(trend)=6.20E-01	No significant association was observed. No significant association was observed.	Negative
rs16941070	NTRK3	A/C	Allelic association: OR=1.2, P-value = 1.71E-01, P-value(trend)=1.66E-01	No significant association was observed. No significant association was observed.	Negative
rs16941001	NTRK3	A/T	Allelic association: OR=1.419, P-value = 9.51E-02, P-value(trend)=1.03E-01	No significant association was observed. No significant association was observed.	Negative
rs16941252	NTRK3	T/C	Allelic association: OR=1.064, P-value = 7.89E-01, P-value(trend)=7.84E-01	No significant association was observed. No significant association was observed.	Negative
rs16941174	NTRK3	A/G	Allelic association: OR=1.07, P-value = 7.77E-01, P-value(trend)=7.79E-01	Significant associations were found . Significant associations were found .	Positive
rs16941328	NTRK3 MED28P6	A/G	Allelic association: OR=1.596, P-value = 6.06E-03, P-value(trend)=6.12E-03	Significant associations were found . Significant associations were found .	Positive
rs16941261	NTRK3	C/G	Allelic association: OR=1.743, P-value = 1.41E-04, P-value(trend)=5.73E-05	Significant associations were found . Significant associations were found .	Positive
rs16941593	NTRK3	A/C	Allelic association: OR=0.9165, P-value = 6.55E-01, P-value(trend)=6.45E-01	No significant association was observed. No significant association was observed.	Negative
rs16941331	NTRK3	C/A	Allelic association: OR=0.8635, P-value = 3.23E-01, P-value(trend)=3.38E-01	No significant association was observed. No significant association was observed.	Negative
rs16941600	NTRK3	T/C	Allelic association: OR=1.149, P-value = 3.27E-01, P-value(trend)=3.23E-01	No significant association was observed. No significant association was observed.	Negative
rs16941599	NTRK3	A/C	Allelic association: OR=1.256, P-value = 2.19E-01, P-value(trend)=2.27E-01	No significant association was observed. No significant association was observed.	Negative
rs17765281	NTRK3-AS1 NTRK3	A/G	Allelic association: OR=1.129, P-value = 6.13E-01, P-value(trend)=6.08E-01	No significant association was observed. No significant association was observed.	Negative
rs17755717	NTRK3	A/G	Allelic association: OR=1.521, P-value = 8.08E-03, P-value(trend)=4.66E-03	Significant associations were found . Significant associations were found .	Positive
rs17830422	NTRK3	C/T	Allelic association: OR=0.9102, P-value = 7.08E-01, P-value(trend)=7.14E-01	No significant association was observed. No significant association was observed.	Negative
rs17831280	NTRK3	T/C	Allelic association: OR=2.25, P-value = 9.63E-04, P-value(trend)=1.78E-03	Significant associations were found . Significant associations were found .	Positive
rs17842141	NTRK3	T/C	Allelic association: OR=0.9868, P-value = 9.32E-01, P-value(trend)=9.31E-01	No significant association was observed. No significant association was observed.	Negative
rs1863482	NTRK3	A/G	Allelic association: OR=0.7533, P-value = 1.69E-01, P-value(trend)=1.65E-01	No significant association was observed. No significant association was observed.	Negative
rs1863490	NTRK3	G/C	Allelic association: OR=0.827, P-value = 3.23E-01, P-value(trend)=3.01E-01	No significant association was observed. No significant association was observed.	Negative
rs1870736	NTRK3	G/C	Allelic association: OR=0.9119, P-value = 4.75E-01, P-value(trend)=4.85E-01	No significant association was observed. No significant association was observed.	Negative
rs1948066	NTRK3	T/C	Allelic association: OR=1.387, P-value = 1.96E-02, P-value(trend)=2.21E-02	Significant associations were found . Significant associations were found .	Positive
rs1986826	NTRK3	C/T	Allelic association: OR=0.9491, P-value = 7.19E-01, P-value(trend)=7.13E-01	No significant association was observed. No significant association was observed.	Negative
rs2009966	NTRK3	A/G	Allelic association: OR=1.337, P-value = 2.69E-02, P-value(trend)=2.83E-02	Significant associations were found . Significant associations were found .	Positive
rs2018052	NTRK3	T/C	Allelic association: OR=0.8311, P-value = 1.58E-01, P-value(trend)=1.62E-01	No significant association was observed. No significant association was observed.	Negative
rs2043516	NTRK3	T/C	Allelic association: OR=0.9214, P-value = 5.95E-01, P-value(trend)=5.90E-01	No significant association was observed. No significant association was observed.	Negative
rs2081556	NTRK3	T/A	Allelic association: OR=0.7945, P-value = 2.52E-01, P-value(trend)=2.40E-01	No significant association was observed. No significant association was observed.	Negative
rs2114252	NTRK3	A/C	Allelic association: OR=1.718, P-value = 1.44E-04, P-value(trend)=5.58E-05	Significant associations were found . Significant associations were found .	Positive
rs2117655	NTRK3	C/A	Allelic association: OR=1.15, P-value = 3.01E-01, P-value(trend)=3.01E-01	No significant association was observed. No significant association was observed.	Negative
rs2349054	NTRK3	A/C	Allelic association: OR=0.7945, P-value = 2.52E-01, P-value(trend)=2.40E-01	No significant association was observed. No significant association was observed.	Negative
rs3743165	NTRK3	G/A	Allelic association: OR=1.022, P-value = 8.74E-01, P-value(trend)=8.72E-01	No significant association was observed. No significant association was observed.	Negative
rs3803409	NTRK3	G/A	Allelic association: OR=0.9303, P-value = 5.87E-01, P-value(trend)=5.86E-01	No significant association was observed. No significant association was observed.	Negative
rs3784410	NTRK3	T/C	Allelic association: OR=0.9308, P-value = 5.82E-01, P-value(trend)=5.93E-01	No significant association was observed. No significant association was observed.	Negative
rs3784406	NTRK3 MED28P6	T/C	Allelic association: OR=1.255, P-value = 8.12E-02, P-value(trend)=8.50E-02	No significant association was observed. No significant association was observed.	Negative
rs3784405	NTRK3 MED28P6	C/T	Allelic association: OR=1.816, P-value = 7.38E-05, P-value(trend)=3.08E-05	No significant association was observed. No significant association was observed.	Negative
rs4404039	NTRK3	T/A	Allelic association: OR=1.018, P-value = 8.97E-01, P-value(trend)=8.93E-01	No significant association was observed. No significant association was observed.	Negative
rs4392026	NTRK3	C/G	Allelic association: OR=1.208, P-value = 2.15E-01, P-value(trend)=2.11E-01	No significant association was observed. No significant association was observed.	Negative
rs4243096	NTRK3	T/C	Allelic association: OR=1.01, P-value = 9.45E-01, P-value(trend)=9.43E-01	No significant association was observed. No significant association was observed.	Negative
rs3963196	NTRK3	G/C	Allelic association: OR=0.8173, P-value = 3.12E-01, P-value(trend)=2.99E-01	No significant association was observed. No significant association was observed.	Negative
rs4887326	NTRK3	A/G	Allelic association: OR=0.9654, P-value = 8.14E-01, P-value(trend)=8.06E-01	No significant association was observed. No significant association was observed.	Negative
rs4887212	NTRK3	T/C	Allelic association: OR=1.182, P-value = 1.98E-01, P-value(trend)=2.00E-01	No significant association was observed. No significant association was observed.	Negative
rs4887211	NTRK3	G/A	Allelic association: OR=0.7964, P-value = 2.57E-01, P-value(trend)=2.45E-01	No significant association was observed. No significant association was observed.	Negative
rs4887205	NTRK3	T/C	Allelic association: OR=0.8722, P-value = 3.07E-01, P-value(trend)=3.21E-01	No significant association was observed. No significant association was observed.	Negative
rs4887376	NTRK3	G/T	Allelic association: OR=1.275, P-value = 5.75E-02, P-value(trend)=6.28E-02	No significant association was observed. No significant association was observed.	Negative
rs4887364	NTRK3	C/T	Allelic association: OR=1.688, P-value = 2.28E-04, P-value(trend)=8.95E-05	Significant associations were found . Significant associations were found .	Positive
rs4887329	NTRK3	A/G	Allelic association: OR=0.9881, P-value = 9.31E-01, P-value(trend)=9.31E-01	No significant association was observed. No significant association was observed.	Negative
rs4887328	NTRK3	T/A	Allelic association: OR=0.8905, P-value = 4.17E-01, P-value(trend)=4.12E-01	No significant association was observed. No significant association was observed.	Negative
rs4887408	NTRK3	T/G	Allelic association: OR=1.089, P-value = 6.22E-01, P-value(trend)=6.21E-01	No significant association was observed. No significant association was observed.	Negative
rs6496455	NTRK3	A/G	Allelic association: OR=0.8452, P-value = 3.59E-01, P-value(trend)=3.71E-01	No significant association was observed. No significant association was observed.	Negative
rs4887382	NTRK3	C/T	Allelic association: OR=0.738, P-value = 1.33E-01, P-value(trend)=1.26E-01	No significant association was observed. No significant association was observed.	Negative
rs4887401	NTRK3 NTRK3-AS1	T/C	Allelic association: OR=1.164, P-value = 3.45E-01, P-value(trend)=3.33E-01	No significant association was observed. No significant association was observed.	Negative
rs6496466	NTRK3	C/T	Allelic association: OR=1.684, P-value = 3.63E-04, P-value(trend)=2.34E-04	Significant associations were found . Significant associations were found .	Positive
rs6496469	NTRK3	G/A	Allelic association: OR=1.761, P-value = 2.11E-04, P-value(trend)=8.44E-05	Significant associations were found . Significant associations were found .	Positive
rs6496461	NTRK3	C/T	Allelic association: OR=1.562, P-value = 3.07E-02, P-value(trend)=2.84E-02	Significant associations were found . Significant associations were found .	Positive
rs6496465	NTRK3 MED28P6	A/G	Allelic association: OR=1.252, P-value = 8.44E-02, P-value(trend)=8.93E-02	No significant association was observed. No significant association was observed.	Negative
rs7164376	NTRK3	T/C	Allelic association: OR=0.9441, P-value = 6.98E-01, P-value(trend)=7.01E-01	No significant association was observed. No significant association was observed.	Negative
rs7164988	NTRK3-AS1 NTRK3	G/A	Allelic association: OR=1.181, P-value = 2.81E-01, P-value(trend)=2.86E-01	No significant association was observed. No significant association was observed.	Negative
rs7161806	NTRK3	A/G	Allelic association: OR=0.8956, P-value = 3.89E-01, P-value(trend)=3.78E-01	No significant association was observed. No significant association was observed.	Negative
rs7163473	NTRK3	C/A	Allelic association: OR=0.9491, P-value = 7.17E-01, P-value(trend)=7.11E-01	No significant association was observed. No significant association was observed.	Negative
rs7166186	NTRK3	A/T	Allelic association: OR=0.9612, P-value = 7.89E-01, P-value(trend)=7.85E-01	No significant association was observed. No significant association was observed.	Negative
rs7167737	NTRK3	C/A	Allelic association: OR=1.253, P-value = 1.13E-01, P-value(trend)=1.14E-01	No significant association was observed. No significant association was observed.	Negative
rs7165500	NTRK3	T/C	Allelic association: OR=1.037, P-value = 8.55E-01, P-value(trend)=8.55E-01	No significant association was observed. No significant association was observed.	Negative
rs7165979	NTRK3	C/G	Allelic association: OR=0.7784, P-value = 7.89E-02, P-value(trend)=8.85E-02	No significant association was observed. No significant association was observed.	Negative

Genes reported by this study for BD (count: 1)