SNP Report

Basic Info

Name	rs977581 dbSNP Ensembl
Location	chr18:9119037 - 9119037(1)
Variant Alleles	T/G
Ancestral Allele	T
Minor Allele	T
Minor Allele Frequence	0.446286
Functional Annotation	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000577703, ENST00000582375, ENST00000583081, ENST00000583375); intron_variant(ENST00000318388, ENST00000400033, ENST00000474350, ENST00000483511, ENST00000578850, ENST00000579126); non_coding_transcript_variant(ENST00000474350, ENST00000483511, ENST00000578850, ENST00000579126); upstream_gene_variant(ENST00000465096, ENST00000579467)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Zhang, J.,2009	G/T	G	Allelic association: Odds ratio=1.019, P-value = 0.899; Geno...... Allelic association: Odds ratio=1.019, P-value = 0.899; Genotypic association: P-value = 0.463 More...	No significant association was observed No significant association was observed	Negative
Xu, C., 2008			Genotypic P-value = 0.1650; Allelic P-value = 0.0440, OR (9...... Genotypic P-value = 0.1650; Allelic P-value = 0.0440, OR (95% CI)=1.59 (1.01-2.52). X²=4.04 More...	Statistically significant allelic association of SNP rs97758...... Statistically significant allelic association of SNP rs977581 with BD and BD I was also detected, but significance was not retained after Bonferroni correction. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	18p11.22	6(5/1/0)

SNPs in LD with rs977581 (count: 38) View in gBrowse (chr18:9094247..9284604 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 38)

rs_ID	Functional Annotation	r²[population]
rs6506644	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.821[CHB]
rs7229883	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.819[CHB]
rs9946695	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.909[CHB]; 0.867[JPT]
rs9946468	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.959[CEU]; 0.906[CHB]; 0.913[JPT]
rs4797356	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.953[JPT]
rs4078337	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 0.913[JPT]
rs7235514	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.821[CHB]
rs8087306		0.813[CHB]; 0.909[JPT]
rs4797361	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.91[CHB]; 0.911[JPT]
rs6506649	downstream_gene_variant; intron_variant; upstream_gene_variant	0.867[CHB]; 0.911[JPT]
rs4130178	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.831[CHB]
rs4798772	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.953[JPT]
rs7228251	3_prime_UTR_variant; downstream_gene_variant	0.956[CEU]; 0.905[CHB]; 0.909[JPT]
rs2276095	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	0.831[CHB]
rs8089693	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.907[CHB]; 0.909[JPT]
rs7504603	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.95[CEU]; 0.805[JPT]
rs9652952	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.821[CHB]; 0.849[JPT]
rs7506291	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CHB]; 0.953[JPT]
rs8092613	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.831[CHB]
rs4131992	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.953[JPT]
rs1893198	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.953[CHB]; 0.909[JPT]
rs8083078	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.827[CHB]
rs11661711	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 0.906[JPT]
rs9960129	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.956[CEU]; 0.953[CHB]; 0.861[JPT]
rs4798791	3_prime_UTR_variant; downstream_gene_variant; missense_variant; NMD_transcript_variant; upstream_gene_variant	0.956[CEU]; 0.909[CHB]; 0.909[JPT]
rs9948560	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.947[CEU]; 1.0[CHB]; 0.946[JPT]
rs874250	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.862[CHB]
rs9945360	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.953[JPT]
rs4603624	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.917[CEU]; 0.91[CHB]; 0.913[JPT]
rs12958093	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]
rs894755	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.913[CEU]; 0.899[CHB]; 0.911[JPT]
rs4798786	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.953[CHB]; 0.909[JPT]
rs4798778	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.956[CEU]; 0.953[JPT]
rs4798776	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.948[CEU]; 0.866[CHB]; 0.819[JPT]
rs17413793	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.956[CEU]; 0.953[CHB]; 0.909[JPT]
rs4148967	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.913[JPT]
rs2155707	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.917[CEU]; 0.91[CHB]; 0.913[JPT]
rs9947027	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 0.867[JPT]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)